Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Structurally-modified antibody – immunoglobulin – or fragment...
Reexamination Certificate
2007-07-25
2010-12-28
Huynh, Phuong (Department: 1644)
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Structurally-modified antibody, immunoglobulin, or fragment...
C424S141100, C424S142100, C424S143100, C424S530000, C424S531000, C530S387300, C530S388100, C530S388150, C530S388220, C530S380000
Reexamination Certificate
active
07858087
ABSTRACT:
The present invention is directed to a composition and method for enhancing the complement-mediated cytotoxicity of therapeutic antibodies for their target cells (i.e. those cells displaying the target epitope). More particularly the present invention enhances the efficacy of such therapies by providing a supplemental source of complement.
REFERENCES:
patent: 5736137 (1998-04-01), Anderson et al.
patent: 6455043 (2002-09-01), Grillo-Lopez
patent: 6572856 (2003-06-01), Taylor et al.
Van der Kolk et al, British J Haematology 115: 807-811, 2001.
Golay et al, Blood 95(12): 3900-3908, 2000.
Harjunpaa, A. et al., Scand. J. Immunol. 51:634-641 (2000).
Gilleece, M.H. et al., Blood, 82(3):807-812 (1993).
Reff, M.E. et al., “Depletion of B Cells in Vivo by a Chimeric Mouse Human Monoclonal Antibody to CD20,” Blood, vol. 83, No. 2, 1994, pp. 435-445.
Van Der Kolk, L.E. et al., “Complement activation plays a key role in the side-effects of rituximab treatment,” British Journal of Haematology, 115, 2001, pp. 807-811.
Kennedy Adam
Lindorfer Margaret A.
Solga Michael D.
Taylor Ronald P.
Barnes & Thornburg LLP
Huynh Phuong
University of Virginia Patent Foundation
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