Enhancing the efficacy of immunotherapies by supplementing...

Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,...

Reexamination Certificate

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C424S133100, C424S155100, C424S094200

Reexamination Certificate

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10486438

ABSTRACT:
The present invention is directed to a composition and method for enhancing the complement-mediated cytotoxicity of therapeutic antibodies for their target cells (i.e. those cells displaying the target epitope). More particularly the present invention enhances the efficacy of such therapies by providing a supplemental source of complement.

REFERENCES:
Harjunpaa, A et al. Scand. J. Immunol. [2000] 51:634-641.
Gilleece, MH et al. Blood [1993] 82(3):807-812.

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