Enhancing the anti-tumor effect of melphalan with L-amino acid o

Details Enhancing the anti-tumor effect of melphalan with L-amino acid o Enhancing the anti-tumor effect of melphalan with L-amino acid o

1993-04-08

1995-04-18

Robinson, Douglas W.

Drug, bio-affecting and body treating compositions

Enzyme or coenzyme containing

Oxidoreductases

424 941, 514564, A61K 3750, A61K 3748, A61K 31195

Patent

active

054076722

ABSTRACT:
L-amino acid oxidase is utilized to reduce plasma level of large neutral amino acids to allow the opportunity of increased melphalan transport into tumors and melphalan is administered when the plasma level of L-amino acid oxidase is sufficiently low so the gain from increased transport outweighs the loss from L-amino acid oxidase-mediated metabolism of melphalan.

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