Drug – bio-affecting and body treating compositions – Enzyme or coenzyme containing – Hydrolases
Patent
1996-12-31
1998-02-17
Rollins, John W.
Drug, bio-affecting and body treating compositions
Enzyme or coenzyme containing
Hydrolases
514 2, A61K 3846, A61K 3800
Patent
active
057188971
ABSTRACT:
A method of enhancing the migration and proliferation of keratinocytes in wound healing or in the growth of artificial skin grown in vitro. The wound is contacted with (a) an effective amount of purified Clostridiopeptidase A collagenase that is substantially free from other proteinases and (b) an amount of a growth factor that increases the effects of said collagenase. The artificial skin is grown upon biomatrices previously synthesized by living cells and digested with Clostridiopeptidase A collagenase while in the presence of (a) an effective concentration of purified Clostridiopeptidase A collagenase substantially free from other proteinases and (b) a growth factor in a concentration effective to increase the effectiveness of said collagenase.
REFERENCES:
patent: 5393792 (1995-02-01), Stern et al.
patent: 5514370 (1996-05-01), Stern et al.
--, "Exp. Cell. Res." 196:114-120 (1991).
Plottel Roland
Rollins John W.
Trustees of Tufts College
Uphan John D.
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