Enhancing drug delivery to the brain

Details Enhancing drug delivery to the brain Enhancing drug delivery to the brain

1987-08-21

1989-05-30

Gray, Bruce D.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

560 38, 560 47, A61K 31245, C07C10164

Patent

active

048351822

ABSTRACT:
Tertiary butyl esters of anticancer drugs are provided which have the following formula: ##STR1## wherein R.sub.1 and R.sub.2 are the same or different and are selected from the group consisting of H, F, Cl, Br, and I and R.sub.2 can also be NH.sub.2 ;

REFERENCES:
Greig, Cancer Treatment Reviews, (1984), 11, 157-186.
Greig, Cancer Treatment Reviews, (1987), 14, 1-28.
Greig et al., Cancer Chemother. Pharmacol (1988).
Afanas'eva et al., Chemical Abstracts, vol. 88, No. 152189y (1978).

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