Enhancing cholinergic activity with 5-substituted 1-[4-(1-pyrrol

Details Enhancing cholinergic activity with 5-substituted 1-[4-(1-pyrrol Enhancing cholinergic activity with 5-substituted 1-[4-(1-pyrrol

1988-07-05

1989-05-23

Schwartz, Richard A.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

5142355, 514255, 514326, 514356, 514422, 544 60, 544111, 544141, 544372, 546208, 548146, 548518, 548551, A61K 3140, A61K 3154, C07D207416

Patent

active

048331392

ABSTRACT:
There are disclosed compounds of the formula ##STR1## where R.sub.1 is loweralkoxycarbonyl, --CH.sub.2 OH or --CONR.sub.3 R.sub.4, R.sub.3 and R.sub.4 being independently hydrogen, loweralkyl or arylloweralkyl; and R.sub.2 is --CH.sub.2 CH.dbd.CH.sub.2, ##STR2## R.sub.5 and R.sub.6 being independently loweralkyl or alternatively the group -NR.sub.5 R.sub.6 as a whole being ##STR3## R.sub.7 being hydrogen, loweralkyl or arylloweralkyl; which are useful for enhancing cholinergic activity in mammals and hence for the treatment of various memory dysfunctions characterized by decreased cholinergic function such as Alzheimer's disease.

REFERENCES:
patent: 4670456 (1987-06-01), Weber et al.

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