Enhances LAK cell activation by treatment of human peripheral bl

Details Enhances LAK cell activation by treatment of human peripheral bl Enhances LAK cell activation by treatment of human peripheral bl

1989-07-21

1992-04-28

Draper, Garnette D.

Drug, bio-affecting and body treating compositions

Extract, body fluid, or cellular material of undetermined...

Blood

424529, 424577, 424578, 424 9, 424 851, 424 852, 4352401, 4352402, 43524021, 43524025, 435948, 514 21, 514885, A61K 3514, C12N 508

Patent

active

051087600

ABSTRACT:
There is provided an improved process for enhanced LAK cell activation wherein the peripheral blood mononuclear cells are treated with an amino acid amide to yield depletion, prior to the lymphocytes being cultured at high density. Also provided are pharmaceutical compositions and methods of using them in combination with IL-2 to treat cancer in a mammal.

REFERENCES:
patent: 4690916 (1987-09-01), Rosenberg
patent: 4849329 (1989-07-01), Leuny et al.
Shaw et al., Cancer Immunol. Immunother, 27, 1988, pp. 255-260.
Mills et al. The Journal Immunol 125 (5) 1980, pp. 1904-1909.
McCrady et al., Cancer Res 48, 1988, pp. 635-640.
Eggermont et al., Br. J. Cancer 58, 1988, pp. 410-414.
McCrady et al., Lymphokine Res 6(1) 1987, pp. 45-57.

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