Enhancer tolerant pressure sensitive adhesives for transdermal d

Details Enhancer tolerant pressure sensitive adhesives for transdermal d Enhancer tolerant pressure sensitive adhesives for transdermal d

1997-10-28

2000-06-20

Williamson, Michael A.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Web, sheet or filament bases; compositions of bandages; or...

526304, 526306, 5263031, 428343, 428355, 428515, 428520, 604304, 604308, A61F 1302

Patent

active

060775270

ABSTRACT:
Pressure sensitive adhesive compositions for use in transdermal drug delivery systems comprising an adhesive composition which is tolerant to plasticization by cutaneous penetration enhancers contained in the transdermal drug formulation are disclosed. Specifically, the pressure sensitive adhesive composition of the present invention comprises an acrylic copolymer prepared from (i) at least 40% by weight of th total monomer composition of alkyl acrylate monomers with a Tg of -90 to 0.degree. C., (ii) 0-15% by weight of the total monomer composition of monomers with a Tg of 0 to 250.degree. C., and (iii) 10-60% by weight of the total monomer composition of substituted acrylamides or methacrylamides having the structural formula: ##STR1## wherein R.sub.1 is H or CH.sub.3,

REFERENCES:
patent: 3558574 (1971-01-01), Doehnert
patent: 4822676 (1989-04-01), Mudge
patent: 5223261 (1993-06-01), Nelson et al.
patent: 5573778 (1996-11-01), Therriault et al.

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