Enhancer sequence for modulating expression in epithelial cells

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...

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4352402, 4353201, 536 231, 536 232, 536 241, 536 245, C12P 2100, C12N 510, C12N 1585, C07H 2104

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055653340

ABSTRACT:
Isolated DNA encompassing the DF3 enhancer as well as a sequence encoding a heterologous polypeptide provides epithelial tissue-selective gene expression of the heterologous polypeptide, useful in methods of therapy.

REFERENCES:
patent: 4740461 (1988-04-01), Kaufman
patent: 5080898 (1992-01-01), Murphy
Struhl (1981) Proceedings of the National Academy of Sciences, vol. 78, pp. 4461-4465.
van Zonneveld et al. (1988) Proceedings of the National Academy of Sciences, vol. 85, pp. 5525-5529.
Sherman et al. (1990) Proceedings of the National Academy of Sciences, vol. 87, pp. 5663-5666.
George et al. (1988) in Macromolecular Sequencing and Synthesis (Alan R. Liss, Inc., New York) pp. 127-149.
Lancaster et al. (1990) Biochem. Biophys. Res. Comm., vol. 173, pp. 1010-1029.
Vleek et al. (1990) Virology, vol. 179, pp. 365-377.
Abe et al., "Sequence Aanalysis Of The 5'Region of the Human DF3 Breast Carcinoma-Associated Antigen Gene", Bio. Biophys. Research Comm., 165:2, pp. 664-649 (1989).
Lundy et al., "Monoclonal Antibody DF3 Correlates with Tumor Differentiation and Hormone Receptor Status in Breast Cancer Patients", Breast Cancer Res. Treat. 5:269-276 (1985).
Abe et al., "Structural Analysis of The DF3 Human Breast Carcinoma-Associated Protein", Cancer Res. 49:2834-2839 (1989).
Abe et al., "Identification of a Family of High Molecular Weight Tumor-Associated Glycoproteins", J. Immun. 139:257-261 (1987).
Abe et al., "Transcriptional Regulation of DF3 Gene Expression in Human MCF-7 Breast Carcinoma Cells", J. Cell. Physio. 143:226-231 (1990).
Abe et al., "Sodium Butyrate Induction of Milk-Related Antigens in Human MCF-7 Breast Carcinoma Cells", Cancer Res. 44:4574-4577 (1984).
Hug et al., "Liposomes for the Transformation Of Eukaryotic Cells", Biochem. Biophys. Acta 1097:1-17(1991).
Neyfakh et al., "Efflux-Mediated Multidrug Resistance in Bacillus subtilis: Similarities and Dissimilarities with the Mammalian System", Proc. Natl. Acad. Sci. USA 88:4781-4785 (1991).
Mc Grath et al., "The Yeast STE6 Gene Encodes a Homologue of the Mammalian Multidrug Resistance P-Glycoprotein", Nature 340:400 (1989).
Melani et al., "Inhibition of Proliferation by c-myb Antisense Oligodeoxynucleotides in Colon Adenocarcinoma Cell Lines that Express c-myb", Cancer Research 51:2897-2901 (Jun. 1, 1991).
Gutierrez et al., "Gene Therapy for Cancer", The Lancet, 339:715-721 (Mar. 21, 1992).

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