Enhancer for eukaryotic expression systems

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...

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4351723, 536 241, C12P 2102, C07H 2104, C12N 1511, C12N 1567

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058495223

ABSTRACT:
An enhancer has been located in the upstream region of the major immediate early gene of human cytomegalovirus and has been isolated, which enhancer is more active than that from SV40 and has a wide host cell spectrum. Hence, it is suitable for eukaryotic expression systems wherein it can be incorporated upstream or downstream of the structural gene or of the regulation region.

REFERENCES:
patent: 5168062 (1992-12-01), Stinski
Greenaway et al., "Human cytomegalovirus DNA: BamHI, EcoRI and PstI restriction endonuclease cleavage maps," Gene, 18:355-360 (1982).
Stinski et al., "Organization and Expression of the Immediate Early Genes of Human Cytomegalovirus,"J. Virol., 46:1-14 (Apr. 1983).
Stenberg et al., "Structural Analysis of the Major Immediate Early Gene of Human Cytomegalovirus," J. Virol., 49:190-199 (Jan. 1984).
Clanton et al., "Neoplastic transformation by a cloned human cytomegalovirus DNA fragment uniquely homoloqous to one of the transforming regions of herpes simplex virus type 2," PNAS-USA, 80:3826-3830 (1983).
Nelson et al., "Structure of the Transforming Region of Human Cytomegalovirus AD169,"J. Virol., 49:109-115 (Jan. 1984).
Gorman et al., "Recombinant Genomes Which Express Chloramphenicol Acetyl-transferase in Mammalian Cells," Mol. Cell. Biol., 2:1044-1051 (1982).
Laimins et al., "Host-specific activation of transcription by tandem repeats from simian virus 40 and Moloney murine sarcoma virus," PNAS-USA, 79:6453-6457 (1982).
Kaufman et al., "Construction of a Modular Dihydrofolate Reductase cDNA Gene: Analysis of Signals Utilized for Efficient Expression," Mol. Cell. Biol., 2:1304-1319 (1982).
Dynan et al., "Isolation of Transcription Factors that Discriminate between Different Promoters Recognized by RNA Polymerase II," Cell, 32:669-680 (1983).
Breathnach et al., "Plasmids for the cloning and expression of full-length double-stranded cDNAs under control of the SV40 early or late gene promoter," Nucl. Acids Res., 11:7119-7136 (1983).
Kaufman et al., "Growth-Dependent Expression of Dihydrofolate Reductase mRNA from Modular cDNA Genes," Mol. Cell. Biol., 3:1598-1608 (1983).
Jahn et al., Journal of Virology, 49:363-370 (1984).
Weber et al.. Cell, 36:983-992 (1984).
Thomsen et al., Proc. Natl. Acad. Sci., 81:659-663 (1984).
Banerji et al., Cell 33:729-740 (1983).
Gillies et al., Cell, 33:717-728 (1983).
Okazaki et al., EMBO J., 4:2589-2595 (1985).
Theisen et al., EMBO J., 5:719-724 (1986).
Garabedian et al., Cell, 45:859-867 (1986).
Ciliberto et al., Cell, 41:531-540 (1985).
Edlund et al., Science, 230:912-916 (1985).
Boulet et al., Proc. Natl. Acad. Sci. (USA), 83:3599-3603 (1986).

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