Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,...
Patent
1997-10-30
2000-06-13
Johnson, Nancy A.
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
4241351, 4241381, 435 691, 435 696, 514 2, 514 44, 5303871, 5303873, 5303877, 53038822, 536 2353, A61K 39395, C07K 1618, C07K 1630, C07H 2104
Patent
active
060746408
ABSTRACT:
The present invention provides a method of enhancing the chemosensitivity and radiosensitivity of a neoplastic cell expressing an oncoprotein that stimulates proliferation of the cell, comprising introducing into the cell a nucleic acid molecule encoding an antibody homologue, wherein the antibody homologue is expressed intracellularly and binds to the oncoprotein intracellularly in the endoplasmic reticulum of the cell. The present invention is also directed to a method for enhancing the inhibition of proliferation of a neoplastic cell expressing an oncoprotein that stimulates proliferation of the cell, comprising the steps of: introducing into the cell a nucleic acid molecule encoding an antibody homologue, wherein the antibody homologue is expressed intracellularly and binds to the protein intracellularly; and contacting said cell with an anti-neoplastic agent.
REFERENCES:
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Deshane, J. Clin. Invest 96:2980, 1995.
Buchsbaum Donald J.
Curiel David T.
Stackhouse Murray
Adler Benjamin Aaron
Johnson Nancy A.
UAB Research Foundation
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