Enhancement of transfection of DNA into the liver

Details Enhancement of transfection of DNA into the liver Enhancement of transfection of DNA into the liver

2007-05-01

2007-05-01

Whiteman, Brian (Department: 1635)

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Genetically modified micro-organism, cell, or virus

Reexamination Certificate

active

10483189

ABSTRACT:
A method for transfection of DNA or RNA encoding apo A1 into the liver to regulate lipid metabolism comprises injection of a solution containing the DNA or RNA gene into the liver in combination with gas microbubbles or microspheres and using ultrasound to induce the transfection of the DNA or RNA in the liver.

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Product insert for Optison ultrasound contrast agent, “Optison (Perflutren Protein-Type A Microspheres for Injection, USP”, revised Jun. 2003.

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