Enhancement of transdermal drug delivery using monoalkyl phospha

Details Enhancement of transdermal drug delivery using monoalkyl phospha Enhancement of transdermal drug delivery using monoalkyl phospha

1993-12-08

1994-10-25

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Web, sheet or filament bases; compositions of bandages; or...

514946, A61F 1300

Patent

active

053587154

ABSTRACT:
Pharmaceutical formulations, transdermal drug delivery devices, and methods of drug delivery using the formulations and devices of the invention are disclosed which make it possible to enhance the rate of transdermal drug delivery of pharmaceutically active compounds and in particular molsidomine. The rate of drug delivery is increased by using absorption promoters which include monoalkyl phosphates and salts thereof alone or in combination with other absorption promoters such as polyhydroxyl esters, longchain fatty acids, polyhydroxyl alcohols and terpenes. Particular combinations of monoalkyl phosphates with one or more additional absorption promoters provides synergistic effects with respect to enhancing the rate of drug delivery of certain pharmaceutically active drugs such as molsidomine.

REFERENCES:
patent: 4731241 (1988-03-01), Yamada et al.
patent: 5091186 (1992-02-01), Miranda et al.
Takeshita et al., "Long-lasting effect of oral molsydomine on exercise performance" Circulation (1977) 55(2):401-407.
Noack et al., "Molecular aspects underlying the vasodilator action of molsidomine" Journal of Cardiovascular Pharmacology (1989) 14(Supplement 11):S1-S5.
Ostrowski et al., "Pharmacokinetics of molsidomine in humans" American Heart Journal (1985) 109(3):641-643.
Kukovetz et al., "Mechanism of vasodilation by molsidomine" American Heart Journal (1985) 109(3):637-640.
Schmutzler et al., "Conclusions" American Heart Journal (1985)109(3):723-724.

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