Enhancement of skin pigmentation by prostaglandins

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...

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424 59, 424401, A61K7/42;7/40

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active

059050918

ABSTRACT:
A composition comprising a carrier and prostaglandin effective in stimulating synthesis of melanin in a human melanocyte thereby enhancing pigmentation of the human skin and optionally comprising a lysosomotropic agent, a phosphodiesterase inhibitor, and/or methylxanthines, and a method of use of the composition. Use of this composition promotes tanning of the human skin and increases photoprotection from ultraviolet radiation.

REFERENCES:
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patent: 5219885 (1993-06-01), Frolich et al.
patent: 5554359 (1996-09-01), Fuller
Bryan B. Fuller and Joyce Lebowitz, "Decay of Hormone Responsiveness in Mouse Melanoma Cells in Culture as a Function of Cell Density", Journal of Cellular Physiology, vol. 103, pp. 279-287, 1980.
Frank L. Meyskens, Jr., Elizabeth B. Bergludn, Debra F. Saxe, Bryan B. Fuller, Laura Z. Pacelli, Jennifer D. Hall, and C. George Ray, "Biological and Biochemical Properties of a Human Uveal Melanocyte-Derived Cell Line", In Vitro, vol. 16, No. 9, pp. 775-780, 1980.
Bryan B. Fuller and Frank L. Meyskins, "Endocrine Responsiveness in Human Melanocytes and Melanoma Cells in Culture", JNCL, vol. 66, No. 5, pp. 799-802, May 1981.
James J. Nordlund, Cynthia E. Collins, and Lawrence A. Rheins, "Prostaglandin E.sub.2 and D.sub.2 but Not MSH Stimulate the Proliferation of Pigment Cells in the Pinnal Epidermis of the DBA/2 Mouse", J. Invest. Dermatol., vol. 86, pp. 433-437, 1986.
Alice P. Pentland and Philip Needleman, "Modulation of Keratinocyte Proliferation In Vitro by Endogenous Prostaglandin Synthesis", J. Clin. Invest., vol. 77, Jan. 1986.
Yasushi Tomita, Masatoshi Iwamoto, Takayuki Masuda, and Hachiro Tagami, J. Invest. Dermatol., vol. 89, pp. 299-301, 1987.
Phillip R. Gordon, Claire P. Mansur, and Barbara A. Gilchrest, "Regulation of Human Melanocyte Growth, Dendricity, and Mealnization by Keratinocyte Derived Factors", J. Invest. Dermatol., vol. No. 92, pp. 565-572, 1989.
Mitsuru Iwata, Shoko Iwata, Mark A Everett, and Bryan B. Fuller, "Hormonal Stimulation of Tyrosinase Activity in Human Foreskin Organ Cultures", In Vitro Cell. Dev. Biol., vol. 26, pp. 554-560, Jun. 1990.
"Xalatan" Drug Lasert, Pharmacia & Upjohn, Jun. 3, 1996.
Abdel et al., In Vitro Modulation of Proliferation and Melanization of S91 Melanoma Cells by Prostaglandins, Cancer Research, 3141-3146, Jun. 15, 1987.

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