Enhancement of pharmaceutical activity

Details Enhancement of pharmaceutical activity Enhancement of pharmaceutical activity

1984-07-26

1991-03-19

Friedman, Stanley J.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Liposomes

424417, A61K 3722

Patent

active

050009583

ABSTRACT:
The invention encompasses mixtures of antimicrobial agents coencapsulated in liposomes which when administered in vivo exert an enhanced therapeutic effect. The therapeutic effectiveness of the coencapsulated antimocrobial agents is greater than that of the same combination administered either in solution or as a mixture of liposome populations each containing one of the antimicrobial agents.

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patent: 4241046 (1980-12-01), Papahadjopoulos
patent: 4328222 (1982-05-01), Schmidt
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patent: 4485054 (1984-11-01), Mezei et al.
patent: 4588578 (1986-05-01), Fountain et al.
Goodwan and Gilman "The Pharmacological Bases of Therapeutics" 6th Edition, 1980 McMillan pp. 1097-1102.
Conn, Current Therapy, 1981 L. B. Saunders, pp. 10,23, 569.
Remingtons Pharmaceutical Science 15th Edition Mar. 1975 p. 1130.
Glew et al., Comparative Synergistic Activity of Nafcillin, Oxacillin, and Methicillin in Combination with Gentamicin Against Enterococci, Antimicrobial Agents and Chemotherapy 75, 828-32.

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