Enhancement of NMR imaging of tissue by paramagnetic pyrophospha

Details Enhancement of NMR imaging of tissue by paramagnetic pyrophospha Enhancement of NMR imaging of tissue by paramagnetic pyrophospha

1987-01-29

1989-09-19

Warden, Robert J.

Drug, bio-affecting and body treating compositions

In vivo diagnosis or in vivo testing

Magnetic imaging agent

424603, 128653, 128654, 436173, 436806, A61K 4900

Patent

active

048679631

ABSTRACT:
Nuclear magnetic resonance imaging of animal or human tissue is enhanced when a paramagnetic pyrophosphate compound is administered intraveneously as a contrast agent. The contrast agent is particularly useful in magnetic resonance imaging of area of tissue calcification, such as acute myocardial infarctions. Specific localization of paramagnetic pyrophosphate in ischemic and necrotic muscle cells at the periphery of a myocardial infarction makes accurate localization and sizing of the central infarct and peri-infarct zones possible.

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