Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1994-10-27
1997-05-06
Campbell, Bruce R.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
424450, 4351721, 4351723, 935 52, 935 54, A61K 4800, A61K 9127, C12N 500
Patent
active
056271590
ABSTRACT:
A method is provided for enhancing transfection efficiency of eukaryotic cells comprising contacting said cells with a lipid aggregate comprising nucleic acid and a polycationic lipid composition in the presence of a polycationic compound and serum. The polycationic compound is preferably Polybrene.TM., and the lipid aggregate preferably comprises liposomes of nucleic acid and LipofectAMINE.TM..
REFERENCES:
Brunette et al (1992) Nucleic Acids Research 20:1151.
Zhou et al (1991) Biochimica et BioPhysica Acta 1065:8-14.
Hawley-Nelson Pamela
Jessee Joel A.
Shih Po-Jen
Campbell Bruce R.
Life Technologies Inc.
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