Surgery: light – thermal – and electrical application – Light – thermal – and electrical application – Light application
Patent
1997-10-22
1999-02-02
Lacyk, John P.
Surgery: light, thermal, and electrical application
Light, thermal, and electrical application
Light application
604 49, A61N 506
Patent
active
058658408
ABSTRACT:
The efficacy of a plurality of PDT treatments following at least an initial PDT treatment is enhanced by increasing the neutrophil count of the patient substantially above a normal level. The increase in the neutrophil count leads to a more rapid removal of dead abnormal cells and stroma that have been destroyed, thereby enabling light administered in subsequent PDT treatments to more effectively reach and destroy still living abnormal cells on the surface of the tumor. The accelerated removal of dead tumor cells also enables a more accurate assessment of the treatment progress, since the actual tumor size should be more evident in image of the site. By enabling a tumor to be more rapidly destroyed by multiple PDT treatments, the risk of metastatic spread of abnormal cells away from the treatment site is also reduced.
REFERENCES:
patent: 5257970 (1993-11-01), Doudgerty
patent: 5554150 (1996-09-01), Bousseau et al.
patent: 5649904 (1997-07-01), Gianni
de Vree, Wil J.A., et al., Evidence for an Important Role of Neutrophils in the Efficacy of Photodynamic Therapy in Vivo, Cancer Research, 56, 2908-2911, Jul. 1, 1996.
Mito, Keiichiro, A needle type therapeutic system incorporating laser light and lumin for immunotherapy of cancer growing in deep organs, Journal of Medical Engineering & Technology, vol. 20, No. 3 (May/Jun. 1996), pp. 121-126.
Krosl, Gorazd, et al., Potentiation of Photodynamic Therapy-elicited Antitumor Response by Localized Treatment with Granulocyte-Macrophage Colony-stimulation Factor, Cancer Research, 56, 3281-3286, Jul. 15, 1996.
Korbelik, Mladen, et al., Enhanced Macrophage Cytotoxicity Against Tumor Cells Treated With Photodynamic Therapy, Photochemistry and Photobiology, vol. 60, No. 5, pp. 497-502, 1994.
Ohara, Kiyoshi, M.D., et al., Impact of Biological Clearance on Tumor Radioresponsiveness, Int. J. Radiation Oncology Biol. Phys., vol. 34, No. 2, pp. 389-393, 1996, .COPYRGT.1996 Elsevier Science Inc.
Yamamoto, Nobuto, et al., Photodynamic Immunopotentiation: in vitro Acitvation of Macrophages by Treatment of Mouse Peritoneal Cells with Haematoporphyrin Derivative and light, Eur J Cancer, vol. 27, No. 4, pp. 467-471, 1991. Great Britain, .COPYRGT.1991 Pergamon Press plc.
Anderson Ronald M.
Gibson Roy D.
Lacyk John P.
Light Sciences Limited Partnership
LandOfFree
Enhancement of light activation effect by immune augmentation does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Enhancement of light activation effect by immune augmentation, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Enhancement of light activation effect by immune augmentation will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1112660