Enhancement of learning and memory and treatment of amnesia

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C514S443000, C514S469000, C514S471000, C514S412000, C514S427000, C514S405000, C514S256000

Reexamination Certificate

active

07049334

ABSTRACT:
A method for enhancing learning and memory or treating amnesia. The method includes administrating to a subject in need thereof a compound of the formula (I):A is H, R, or each of Ar1, Ar2, and Ar3, independently, is phenyl, thienyl, furyl, or pyrrolyl; each of R1, R2, R3, R4, R5, and R6, independently, is H, nitro, halogen, R, OH, OR, C(O)OH, C(O)OR, C(O)SH, C(O)SR, C(O)NH2, C(O)NHR, C(O)NRR′, ROH, ROR′, RSH, RSR′, ROC(O)R′OH, NHR, NRR′, RNHR′, or RNR′R″; or R1and R2together, R3and R4together, or R5and R6together are ORO; wherein each of R, R′, and R″, independently is C1˜C6alkyl; and n is 1, 2, or 3. The compound is in an effective amount for enhancing learning and memory or treating amnesia.

REFERENCES:
patent: 5240947 (1993-08-01), Kuo et al.
patent: 5574168 (1996-11-01), Kuo et al.
patent: 6162819 (2000-12-01), Schindler et al.
patent: 6693102 (2004-02-01), Stasch et al.
patent: WO 200116359 (2001-03-01), None
patent: WO 200154771 (2001-08-01), None

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