Enhancement of glutathione levels with glutamine

Details Enhancement of glutathione levels with glutamine Enhancement of glutathione levels with glutamine

1990-09-20

1993-09-28

Schenkman, Leonard

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Radical -xh acid, or anhydride, acid halide or salt thereof...

A61K 31195

Patent

active

052486974

ABSTRACT:
A method of maintaining and/or enhancing tissue or plasma levels of glutathione is provided. Treatment of a mammal with a supranormal amount of glutamine, or a glutamine equivalent, prevents the reduction in tissue glutathione levels associated with exposure of the mammal to a compound capable of oxidative injury to the tissue. Such compounds may be drugs such as chemotherapeutic agents. Administration of a supranormal amount of glutamine or a glutamine equivalent after exposure of a mammal to a compound capable of oxidative injury to the tissue can ameliorate or prevent injury. Treatment of a mammal with glutamine or a glutamine equivalent can also reduce or prevent starvation- or radiation-associated oxidative damage in the tissues.

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