Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Primate cell – per se
Patent
1995-06-05
1997-12-02
Lankford, Blaine
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
Primate cell, per se
435325, 435364, C12N 500
Patent
active
056935340
ABSTRACT:
A method is provided for increasing the fertilization potential of oocytes comprising culturing oocytes in vitro with an effective amount of inhibin, activin, or a combination of inhibin and activin. Preferably the oocytes being cultured are immature. After the culturing step, the oocytes can be fertilized. The oocytes are suitably cryopreserved and thawed before the culturing step.
REFERENCES:
patent: 4845077 (1989-07-01), Hodgen
patent: 5102868 (1992-04-01), Woodruff et al.
patent: 5166190 (1992-11-01), Mather et al.
patent: 5206160 (1993-04-01), Takahashi et al.
Adashi et al., "Antagonistic Interactions of Transforming Growth Factors in the Regulation of Granulosa Cell Differentiation" Endocrinology 119(4):1879-1881 (1986).
Al-Hasani et al., "Cryopreservation of Human Oocytes" Human Reprod. 2:695-700 (1987).
Al-Obaidi et al., "Reproductive Characteristics of Lambs Actively Immunized Early in Life with Inhibin-Enriched Preparations from Follicular Fluid of Cows" J. Reprod. Fert. 81:403-414 (1987).
Baird et al., "Inhibin Levels in Gonadotrophin-Treated Cycles" Ann. NY Acad. Sci. 541:153-161 (1988).
Baker et al., "Present Status of Research on Inhibin: An Appraisal" Clin. Reprod. and Fert. 2:161-174 (1983).
Bramley et al., "Apparent .alpha.-Inhibin Subunit Immunoactivity in Porcine and Ovine Luteal Extracts is Due to Interference by Cytosolic Proteases in the Assay" J. Endocrin. 134:341-352 (1992).
Bremner et al., "Follicle-Stimulating Hormone and Human Spermatogenesis" J. Clin. Invest. 68:1044-1052 (1981).
Buckler et al., "Purified FSH Simulates Production of Inhibin by the Human Ovary" J. Endorcrinol. 122:279-285 (1989).
Byrd, "Gamete Intrafallopian Transfer (Gift)" In Vitro Fertilization and Embryo Transfer: A Manual of Basic Techniques, D.P. Wolf, ed., Plenum Press pp. 265-279 (1988).
Carson et al., "Growth Factors in Ovarian Function" J. Reprod. Fert. 85:735-746 (1989).
Cha et al., "Pregnancy After In Vitro Fertilization of Human Follicular Oocytes Collected from Nonstimulated Cycles, Their Culture In Vitro and Their Transfer in a Donor Oocyte Program" Fert. Steril. 55:109-113 (1991).
Cummins et al., "Increase in Ovulation Rate After Immunization of Merino Ewes with a Fraction of Bovine Follicular Fluid Containing Inhibin Activity" J. Reprod. Fert. 77:365-372 (1986).
D'Agostino et al., "Unilateral Ovariectomy Increases Inhibin Messenger Ribonucleic Acid Levels in Newly Recruited Follicles" Endocrin. 124:310-317 (1989).
de Jong, "Inhibin" Physiol. Rev. 68(2) :555-607 (1988).
de Kretser et al., "The Isolation and Physiology of Inhibin and Related Proteins" Biology of Reproduction 40:33-47 (1989).
DePaolo et al., "Follistatin and Activin: A Potential Intrinsic Regulatory System Within Diverse Tissues" Proc. Soc. Exp. Biol. & Med. 198:500-512 (1991).
Feng et al., "Transforming Growth Factor .beta. Regulates the Inhibitory Actions of Epidermal Growth Factor during Granulosa Cell Differentiation" The Journal of Biological Chemistry 261(30):14167-14170 (Oct. 25, 1986).
Findlay, "The Nature of Inhibin and Its Use in the Regulation of Fertility and Diagnosis of Infertility" Fertil. and Steril. 46(5) :770-783 (1986).
Forage et al., "Immunization Against an Inhibin Subunit Produced by Recombinant DNA Techniques Results in Increased Ovulation Rate in Sheep" J. Endocrin. 114:R1-R4 (1987).
Franchimont et al., "Inhibin and Related Peptides: Mechanisms of Action and Regulation of Secretion" Rev. Fr. Gynecol. Obstet. 83(10):607-611 (1988).
Gerrity et al., "Embryo Transfer" In Vitro Fertilization and Embryo Transfer: A Manual of Basic Techniques, D.P. Wolf, ed., Plenum Press pp. 189-207 (1988).
Gonzalez-Manchon et al., "Activin-A, Inhibin and Transforming Growth Factor-.beta. Modulate Growth of Two Gonadal Cell Lines" Endocrinology 125(3) :1666-1672 (1989).
Hasegawa et al., "Changes in Serum Concentrations of Inhibin During the Estrous Cycle of the Rat, Pig and Cow" Inhibin-Non-Steroidal Regulation of Follicle Stimulating Hormone Secretion, Burger et al., eds., NY:Raven Press vol. 42:119-133 (1987).
Henderson et al., "Increase in Ovulation Rate After Active Immunization of Sheep with Inhibin Partially Purified from Bovine Follicular Fluid" J. Endocrin. 102:305-309 (1984).
Hillier et al., "Effect of Recombinant Activin on Androgen Synthesis in Cultured Human Thecal Cells" J. Clin. Endocrin. Metab. 72(6):1206-1211 (1991).
Hillier et al., "Effect of Recombinant Inhibin on Androgen Synthesis in Cultured Human Thecal Cells" Mol. Cell. Encrin. 75:R1-R6 (1991).
Hsueh et al., "Heterodimers and Homodimers of Inhibin Subunits Have Different Paracrine Action in the Modulation of Lutenizing Hormone-Stimulated Androgen Biosynthesis" Proc. Natl. Acad. Sci. USA 84:5082-5086 (1987).
Hutchinson et al., "Effects of Bovine Inhibin, Transforming Growth Factor-.beta. and Bovine Activin-A on Granulose Cell Differentiation" Biochemical and Biophysical Res. Comm. 146(3):1405-1412 (Aug. 14, 1987).
Ignotz et al., "Transforming Growth Factor-.beta. Stimulates the Expression of Fibronectin and Collagen and Their Incorporation into the Extracellular Matrix" The Journal of Biological Chemistry 261(9): 4337-4345 (Mar. 25, 1986).
Itoh et al., "Activin A Stimulates Meiotic Maturation of the Rat Oocyte In Vitro" Biochem. and Biophys. Res. Comm. 166(3) :1479-1484 (1990).
Lee et al., "Interstitial Cell Cultures Secrete an Activity with Characteristics of the Inhibin .beta.--.beta. Homodimer, Activin" The Molecular and Cellular Endocrinology of the Testis, Cooke and Sharpe, eds., Raven Press vol. 50:21-27 (1988).
Lee et al., "Ovulation Rate and Inhibin Levels in Gonadotrophin-Treated Mice" Aust. J. Biol. Sci 38:115-120 (1985).
Lee et al., "Secretion of Activin by Interstitial Cells in the Testis" Science 243:396-398 (1989).
Lefevre et al., "Absence of Predictive Value of Follicular Inhibin on the Results of Human In Vitro Fertilization" Fert. and Steril.46(2):325-327 (1986).
Malloy et al., "A Laparoscopic Approach to a Program of Gamete Intrafallopian Transfer" Fertil. Steril. 47(2):289 (1987).
Mather et al., "Activin Stimulates Spermatogonial Proliferation in Germ-Sertoli Cell Cocultures from Immature Rat Testis" Endocrinology 127(6):3206-3214 (1990).
McLachlan et al., "Circulating Immunoactive Inhibin in the Luteal Phase and Early Gestation of Women Undergoing Ovulation Induction" Fert. and Steril. 48(6):1001-1005 (1987).
McLachlan et al., "Plasma Inhibin Levels During Gonadotropin-Induced Ovarian Hyperstimulation for IVF: A New Index of Follicular Function?" Lancet pp. 1233-1234 (May 31, 1986).
Mitrani et al., "Activin Can Induce the Formation of Axial Structures and is Expressed in the Hypoblast of the Chick" Cell 63:495-501 (Nov. 2, 1990).
Mondschein et al., "Effects of Transforming Growth Factor-.beta. on the Production of Immunoreactive Insulin-Like Growth Factor I and Progesterone Cultures" Endocrin. 123:1970-176 (1988).
O et al., "Inhibin as an Oocyte Meiotic Inhibitor" Mol. Cell. Endocrin. 62:307-311 (1989).
Osborn et al., "An Assessment of the Factors Causing Embryonic Loss After Fertilization in Vitro" J. Reprod. Fert., Suppl. 36:59-72 (1988).
Pickering et al., "Transient Cooling to Room Temperature Can Cause Irreversible Disruption of the Meiotic Spindle in the Human Oocyte" Fert. Steril. 54:102-108 (1990).
Quigly et al., "Follicular Size and Number in Human In Vitro Fertilization" Fertil. Steril. 38(6) :678 (1982).
Rivier et al., "Immunoneutralization of Endogenous Inhibin Modifies Hormone Secretion and Ovulation Rate in the Rat" Endocrin. 125(1):152-157 (1989).
Rivier et al., "Inhibin-Mediated Feedback Control of Follicle-Stimulating Hormone Secretion in the Female Rat" Science 234:205-208 (1986).
Robertson et al., "Inhibin as an Oocyte Meiotic Inhibitor" Mol. and Cell. Endocrin. 62:307-311 (1989).
Sathananthan et al., "The Effects of Cooling Human Oocytes" Human Reprod. 3:968-977 (1988).
Sathananthan et al., "Effects of Culture and Cryopreservation on Human Oocyte and Embryo Ultrastructure and Function" Ultrastructure of Human Gametogenesis and Early Embryogenesis, van Blerkom et al., eds., Kluwer Academic Pu
Alak Baha M.
Stouffer Richard L.
Wolf Don P.
Woodruff Teresa K.
Genentech Inc.
Hasak Janet E.
Lankford Blaine
Oregon Regional Primate Research Center
LandOfFree
Enhancement of fertilization capability of oocytes does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Enhancement of fertilization capability of oocytes, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Enhancement of fertilization capability of oocytes will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-800676