Drug – bio-affecting and body treating compositions – Lymphokine
Patent
1987-05-05
1990-08-21
Draper, Garnette
Drug, bio-affecting and body treating compositions
Lymphokine
424 88, 424 89, 424 92, 530387, 530391, 530402, 530403, 530404, 530405, 530406, 435 7, 435 693, 4351722, 4352402, A61K 3900, C08H 100, G01N 5300
Patent
active
049504800
ABSTRACT:
A new method is described for eliciting IgG antibody response to proteins or synthetic peptides without the requirement for the use of adjuvants, thereby making it easier and safer to confer protection against pathogenic organisms. The antigen is coupled to a monoclonal antibody, specific for membrane determinants expressed on certain types of mammalian recipient cells, called antigen presenting cells. The monoclonal antibody acts as a "vector" or "delivery vehicle" for targeting foreign antigens onto such recipient cells. This targeting facilitates subsequent antigen recognition by helper T-cells, which are pivotal in helping the induction of antigen-specific IgG responses.
REFERENCES:
patent: 4400376 (1983-08-01), Sanderson
patent: 4634590 (1987-01-01), Cohen et al.
Hopkins et al, "Monoclonal antibodies to sheep lymphocytes, I. Identification of MHC class II molecules on lymphoid tissue and changes in the level of class II expression on lymph-borne cells following antigens stimulation in vivo," Immunology, vol. 59, pp. 433-438, 1986.
Stites et al "Basic and Clinical Immunology" Large Medical Publications, 5th, edition, pp. 71-85, 1984.
Lampson et al, "Two populations of Ia-like molecules on a human B cell line" Journal of Immunology, vol. 125 No. 1, pp. 293-299, 1980.
Barber Brian H.
Carayannotis George
Connaught Laboratories Limited
Draper Garnette
Mohamed Abdel A.
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