Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...
Reexamination Certificate
2005-04-13
2010-02-23
Marschel, Ardin (Department: 1614)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Radical -xh acid, or anhydride, acid halide or salt thereof...
C514S546000, C424S439000
Reexamination Certificate
active
07666909
ABSTRACT:
D-glyceric acid has been found to enhance alcohol metabolism and thereby prevent adverse effects of alcohol consumption. D-glyceric acid is administered concurrently with alcohol, to accelerate the elimination of the alcohol from the body. D-glyceric acid is converted into D-glyceraldehyde and further into glycerol in reactions catalysed by NADH-aldehyde dehydrogenase and NADH-alcohol dehydrogenase complexes, which are produced in excess during alcohol oxidation, in the cells of alcohol-metabolising tissues. In these reactions, the NADH complexes become NAD-aldehyde dehydrogenase and NAD-alcohol dehydrogenase complexes. These complexes in turn accelerate the oxidation of alcohol, which is paralleled by enhancement of acetaldehyde oxidation to metabolically harmless acetic acid. D-glyceric acid or its salt or ester is used for the manufacture of a pharmaceutical preparation for enhancing the metabolism of alcohol. A method of enhancing the metabolism of alcohol in a subject by administering said compounds an effective amount of D-glyceric acid or its salt or ester is disclosed. An oral or parenteral preparation comprising said compounds is also disclosed.
REFERENCES:
patent: 6117868 (2000-09-01), Pfirrmann
patent: 0 508 324 (1992-10-01), None
Eur. J. Biochem. vol. 30, 1972, Herluf I.D. Thieden et al: Effect of Fructose and Glyceraqldehyde on Ethanol Metalbolism in Human Liver and in Rat Liver:, pp. 250-261.
Folia Micobiol, vol. 46, No. 1, 2001, K. Lesova et al: “OR-1-a Mixture of Esters of Glyceric Acid Produced by Penicillium funiculosum and ItsAntitrypsin Activity”, pp. 21-23.
The Merck Index, Twelfth Edition, Sundan Budavari, “An Encyclopedia of Chemicals, Drugs, and Biologicals”. 1996, p. 4493, abstract 4492.
Marschel Ardin
Skinner & Associates
Vakili Zohreh
LandOfFree
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