Enhancement of adoptosis using antisense oligonucleotides

Details Enhancement of adoptosis using antisense oligonucleotides Enhancement of adoptosis using antisense oligonucleotides

1994-02-22

1996-12-10

Rories, Charles C. P.

Chemistry: molecular biology and microbiology

Spore forming or isolating process

536 245, 435 6, C12N 510, C12N 508, C07H 2104, C12Q 168

Patent

active

055830340

ABSTRACT:
A method is disclosed for enhancement of the efficacy of therapeutic treatment for inducing cell death in a cell having an anti-apoptotic gene by the enhancement of apoptosis. An antisense oligonucleotide is disclosed which hybridizes with the nucleic acid sequence of the anti-apoptotic gene. The oligonucleotide is administered to the cell in an amount sufficient to inhibit expression of the gene, thus rendering the cell susceptible to induction of apoptosis, and consequently achieving higher efficacy of therapeutic treatment.

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