Drug – bio-affecting and body treating compositions – Identification or warning feature – Taste or smell or chemical irritation to the eye – nose – or...
Patent
1989-10-26
1992-12-01
Stoll, Robert L.
Drug, bio-affecting and body treating compositions
Identification or warning feature
Taste or smell or chemical irritation to the eye, nose, or...
514109, 514562, A61K 4900, A61K 3143
Patent
active
051679477
ABSTRACT:
The present invention provides a pharmaceutical composition for enhancing gastrointestinal tract absorption of a radioprotective drug comprising a therapeutically effective dosage amount of a bioactive polar radioprotective agent, such as ethiofos, its active metabolites, and pharmaceutically acceptable salts thereof and a chelating agent selected from the group consisting of EDTA, EGTA, citrate and therapeutically acceptable salts thereof.
A method for enhancing the rate of gastrointestinal absorption of radioprotective agents is also provided.
REFERENCES:
patent: 4537772 (1985-08-01), Alexander et al.
patent: 4713246 (1987-12-01), Begum et al.
patent: 4729989 (1988-03-01), Alexander et al.
patent: 4764380 (1988-08-01), Urquhart et al.
patent: 4822773 (1989-04-01), Alexander et al.
Suzuka, et al, Effect of Salicylate and Disodium Ethylenediaminetetraacetic acid on the rat intestinal absorption of defmetazole (1985) Chem. Pharm Bull. 33:4600-4605.
Yamashita et al, Characterization of Enhanced Intestinal Permeability and the Electrophysiological Study on the Effects of Diclofenac and Ethylene-diaminetetraacetic acid, (1985), J. Pharm. Pharmacol 37:512-513.
Fleckenstein et al, Bioavailability and Newer Methods of Delivery of Phosphorothioate Radioprotectors, (1988) Pharmac. Ther. 39: 203-212.
Sayala C.
Southwest Research Institute
Stoll Robert L.
LandOfFree
Enhancement of absorption of radioprotective drugs does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Enhancement of absorption of radioprotective drugs, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Enhancement of absorption of radioprotective drugs will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-502641