Enhanced solubility pharmaceutical solutions

Details Enhanced solubility pharmaceutical solutions Enhanced solubility pharmaceutical solutions

1992-12-18

1994-12-27

Henley, Raymond J.

Drug, bio-affecting and body treating compositions

Designated organic nonactive ingredient containing other...

Carboxylic acid ester

514769, 514772, 5147724, 5147725, 424452, A61K 4700, A61K 4732, A61K 948

Patent

active

053766881

ABSTRACT:
Pharmaceutically acceptable solutions of acidic, basic or amphoteric pharmaceutical agents are disclosed. These solutions are suitable for encapsulation in gelatin capsules for subsequent oral administration and include the pharmaceutical agent, an ion species and a solvent system.

REFERENCES:
patent: 4188373 (1980-02-01), Krezanoski
patent: 4744988 (1988-05-01), Brox
patent: 4780316 (1988-10-01), Brox
patent: 4888239 (1989-12-01), Brox
patent: 5071643 (1991-12-01), Yu et al.
patent: 5141961 (1992-08-01), Coapman
patent: 5200191 (1993-04-01), Steele et al.
Patel et al., "Factors Affecting The Chemical Stability Of Carboxylic Acid Drugs In Enhanced Solubility System (ESS) Softgel Formulations Based On Polyethylene Glycol (PEG)," Drug Development and Industrial Pharmacy, 18(1), 1-19 (Jan., 1992).

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