Enhanced signal-to-noise ratio and sensitivity optical immunoass

Details Enhanced signal-to-noise ratio and sensitivity optical immunoass Enhanced signal-to-noise ratio and sensitivity optical immunoass

1995-06-07

1998-11-03

Chin, Christopher L.

Chemistry: analytical and immunological testing

Involving an insoluble carrier for immobilizing immunochemicals

356317, 356318, 356369, 356445, 385 12, 385129, 385130, 422 8205, 422 8208, 422 8211, 4352871, 4352887, 435808, 436164, 436165, 436172, 436527, 436805, G01N 33543, G01N 33552

Patent

active

058307664

ABSTRACT:
A method of assaying for a ligand in a sample involves incubating the sample in contact with a specific binding partner for the ligand carried on one surface of an optical structure, irradiating the structure at a suitable angle or range of angles to the normal such that the resonance and/or total internal reflection of the radiation occurs within the optical structure and/or the layer of specific binding partner, and analyzing the radiation in order to determine whether, and if desired the extent to which and/or rate at which the generated radiation and/or optical characteristics of the optical structure are altered by complex formation.

REFERENCES:
patent: 4810658 (1989-03-01), Shanks et al.
patent: 4828387 (1989-05-01), Sawyers et al.
patent: 4978503 (1990-12-01), Shanks et al.

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