Enhanced secretion of a polypeptide by a microorganism

Chemistry: molecular biology and microbiology – Vector – per se

Reexamination Certificate

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C536S023400

Reexamination Certificate

active

10928521

ABSTRACT:
Described herein are methods for the enhanced production of secreted proteins. The secretion of a protein of interest having a substantially non-polar carboxy tail is enhanced by the placement of charged amino acid residues at the carboxy terminus either by adding to the native peptide or by replacing, i.e., substituting, the terminal residues of the native peptide.

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