Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1997-04-15
2000-07-11
Arthur, Lisa B.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435 912, 536 2433, C12Q 168, C12P 1934, C07H 2104
Patent
active
060870982
ABSTRACT:
This invention provides methods of (a) diagnosing; (b) determining the stage of; and (c) monitoring the effect of a therapeutic intervention for a renal cell carcinoma in a human subject which comprises detecting the expression of the MN gene. In one embodiment, the method is directed to detection of the renal cell carcinoma known as clear cell carcinoma. In another embodiment, the method is used as a peripheral blood assay. In another embodiment, the method is a polymerase chain reaction assay for amplifying and detecting the presence of the cDNA molecule encoding the MN protein.
REFERENCES:
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Bander Neil H.
Buttyan Ralph
McKiernan James M.
Sawczuk Ihor S.
Arthur Lisa B.
Cornell Research Foundation Inc.
Souaya Jehanne
The Trustees of Columbia University in the City of New York
White John P.
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