Enhanced production of antibodies utilizing insolubilized immune

Details Enhanced production of antibodies utilizing insolubilized immune Enhanced production of antibodies utilizing insolubilized immune

1990-09-07

1992-01-28

Wax, Robert A.

Chemistry: analytical and immunological testing

Involving iga, igd, ige, or igm

424 88, G01N 33563, A61K 3900

Patent

active

050843966

ABSTRACT:
A method for enhancing production of antibodies through immunization with insolubilized immune complexes is disclosed. Purified antigen or heterogeneous antigen mixtures may be combined with polyclonal or monoclonal antibody and the resultant complex bound to an insolubilized matrix to form insolubilized immune complexes. Methods for improving the immunogenicity of a soluble antigen and for producing monoclonal anti-iodiotypic antibodies are also disclosed. Monoclonal antibodies that are specific for a distinct, as yet unrecognized epitope may be produced by another disclosed method . Insolubilized immune complexes, comprising antigen and antibody that is ether directly linked to Sepharose.RTM. or absorbed onto insolubilized protein A, and immunosorbents, comprising antibody absorbed onto insolubilized protein A, are also disclosed.

REFERENCES:
patent: 4829225 (1989-11-01), Morgan, Jr. et al.

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