Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1997-11-12
2000-03-28
Moezie, F. T.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514261, 514 79, 514 48, 514 17, 536 2611, 435240242, 435240243, 435240241, 43524023, 43524024, A61K 3800, A61K 3808
Patent
active
060432233
ABSTRACT:
Improved compositions and methods for increasing permeability of abnormal brain tissue to pharmaceutical agents. Cyclic GMP specific phosphodiesterase inhibitors are combined with bradykinin or a bradykinin analog to provide enhanced permeability of brain capillaries which is limited to abnormal brain tissue. Neuropharmaceutical and neurodiagnostic agents introduced into the bloodstream are directed selectively to the abnormal brain tissue. The pharmaceutical preparation composed of bradykinin or a bradykinin analog and a cyclic GMP specific phosphodiesterase inhibitor may be administered either intravenously or directly into the carotid artery.
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Nakano, S., Matsukado, K. and Black K.L., "Increased Brain Tumor Microvessel Permeability After Intracarotid Bradykinn Infusion Is Mediated by Nitric Oxide," Cancer Research 56, 4027-4031 (1996).
Moezie F. T.
The Regents of the University of California
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