Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Implant or insert
Patent
1995-04-20
1997-10-07
Azpuru, Carlos A.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Implant or insert
5147723, 514781, A61F 202, A61K 4730
Patent
active
056745214
ABSTRACT:
A method of loading a drug into a crosslinked polymer network and protecting the drug from the effects of inactivation is described. The method includes the steps of contacting a biologically active solute (e.g. drug) with: (i) a gel network; (ii) a loading polymer that is somewhat immiscible with the gel; and (iii) a salt, under conditions sufficient for the biologically active solute to selectively partition into the gel and the salt and the loading polymer to be entrained in the gel. A drug delivery system including a polymer gel network and the drug to be delivered is also described. The system also includes a salt and/or a loading polymer. The system protects the drug from loss of activity. In one embodiment, the polymer gel network is capable of expanding or collapsing in response to a change in an environmental condition to which the gel is exposed, the expanding or collapsing sufficient to release the drug into an environment of use.
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Gehrke Steven Henry
Lupton E. C.
Schiller Matthew E.
Uhden Lorelle
Vaid Nitin
Azpuru Carlos A.
University of Cincinnati
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