Enhanced loading of solutes into polymer gels

Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Matrices

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424486, 424488, 424487, 514944, 2523152, 2523154, 2523153, A61K 910, A61K 4732, A61K 4734, A61K 4736

Patent

active

056039557

ABSTRACT:
A method of loading a drug into a crosslinked polymer network and protecting the drug from the effects of inactivation is described. The method includes the steps of contacting of a biologically active solute (i.e., drug) with:(i) a gel network; (ii) a second protectant polymer that is somewhat immiscible with the gel; and (iii) a protectant salt, under conditions sufficient for the biologically active solute to selectively partition into the gel and the protectants to be entrained in the gel. Most preferably, the gel network is a crosslinked gel responsive to a change in an environmental condition to which the gel is exposed.

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