Enhanced large scale cultivation of bordetella pertussis cells f

Details Enhanced large scale cultivation of bordetella pertussis cells f Enhanced large scale cultivation of bordetella pertussis cells f

1986-05-09

1987-10-13

Schain, Howard E.

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Genetically modified micro-organism, cell, or virus

435253, C12N 120, A61K 3902

Patent

active

046997865

ABSTRACT:
A Bordetella pertussis vaccine is prepared by deep tank cultivation using a seed grown in a biphasic culture system. An anion exchange resin in combination with .beta.-lactoglobulin and a Modified Cohen-Wheeler or Modified Stainer-Schlolte medium is used in the process resulting in enhancement of the growth, antigen production and potency of the phase I Bordetella pertussis vaccine. An acellular Bordetella pertussis vaccine derived from the culture broth and cells of Bordetella pertussis useful in preparing an acellular vaccine and which are grown in a medium containing .beta.-lactoglobulin and an anion exchange resin is also disclosed.

REFERENCES:
patent: 3577319 (1971-05-01), Nielsen et al.
patent: 4429046 (1984-01-01), Lin et al.
Kirk-Othmer, Encyclopedia of Chemical Technology, vol. 13, 1969, p. 569.

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