Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing heterocyclic carbon compound having only o – n – s,...
Patent
1992-10-02
1994-12-20
Wax, Robert A.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing heterocyclic carbon compound having only o, n, s,...
435 691, 435 711, 435156, 4351723, 4352402, 4352523, 43525233, 43525234, 4353201, 536 221, 536 231, 536 232, 536 237, C12P 1712, C12P 722, C12N 120, C07H 1900
Patent
active
053745434
ABSTRACT:
DNA molecules encoding a modified tryptophan synthase beta subunit are disclosed. When expressed in a recombinant host microorganism, these polypeptide analogs enable significant levels of intracellular indole production and accumulation. In the presence of an aromatic dioxygenase enzyme, the indole so produced can be converted to indoxyl, which upon exposure to air oxidizes to indigo.
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Amgen Inc.
Chambers Daniel M.
Kim Hyosuk
Levy Ron K.
Odre Steven M.
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