Enhanced implantation, development and maintenance of embryos us

Details Enhanced implantation, development and maintenance of embryos us Enhanced implantation, development and maintenance of embryos us

1994-08-17

1998-01-27

Stanton, Brian R.

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

4351723, 800 2, C12N 585, C12N 1586, C12N 1500

Patent

active

057121567

ABSTRACT:
Disclosed is the in vitro development of mammalian embryos to the implantation stage by culturing the embryos in a medium containing leukemia inhibitory factor (LIF). Inclusion of LIF in the medium containing embryos also enhances the ability of the embryos to develop normally.

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Pease et al. (1990) "Isolation of Embryonic Stem (ES) Cells in Media Supplemented with Recombinant Leukemia Inhibitory Factor (LIF)", Developmental Biology 141, 344-352.
Williams et al. (1988) "Myeloid Leukemia Inhibitory Factor Maintains the Developmental Potential of Embryonic Stem Cells", Nature 366, 684-687.
Pease et al. (1990) "Formation of Germ-Line Chimeras from Embryonic Stem Cells Maintained with Recombinant Leukemia Inhibitory Factor", Experimental Cell Research 190, 209-211.
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Heath et al. (1988) "Regulatory Factors of Embryonic Stem Cells", J. Cell. Sci. Suppl. 10, 257-266.
Hilton et al. (1988) "Purification of a Murine Leukemia Inhibitory Factor from Krebs Ascites Cells", Analytical Biochemistry 173, 359-367.

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