Enhanced immunization and suppression of oral tolerance

Details Enhanced immunization and suppression of oral tolerance Enhanced immunization and suppression of oral tolerance

2002-10-15

2008-11-18

Huff, Sheela J (Department: 1643)

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

C424S185100, C424S277100, C514S012200

Reexamination Certificate

active

07452540

ABSTRACT:
This invention provides for methods of immunizing mammals against tumors expressing a carcinoembryonic antigen using a carcinoembryonic immunogen modified to lack cellular immunosuppressive activity or CD1d binding. The invention further provides for use of a carcinoembryonic immunogen having a region recognized by antibody B9 or L12 modified to inactivate cellular immunosuppressive activity. Methods are also provided for modifying the immunogen by deleting, altering, mutating or truncating the immunosuppressive region. The invention also provides for enhancing cellular immunogenicity of an orally delivered immunogen by co-administration of an agent capable of inhibiting the immunosuppressive activity of carcinoembryonic antigen. Further methods are provided for creating a patient having a carcinoembryonic-antigen-family-member-expressing tumor by immunizing the patient with the carcinoembryonic-antigen-family-member lacking the immunosuppressive region. Pharmaceutical compositions for eliciting an effective immune response to the carcinoembryonic antigen are also provided.

REFERENCES:
patent: 6852320 (2005-02-01), Blumberg
patent: 2003/0022292 (2003-01-01), Gray-Owen et al.
Freshney (Culture of Animal Cells, A Manual of Basic Technique, Alan R. Liss, Inc., 1983, New York, p. 4).
Dermer (Bio/Technology, 1994, 12:320).
Gura (Science, 1997, 278:1041-1042).
Jain (Sci. Am., 1994, 271:58-65).
Taheri et al JBC vol. 275 p. 26935-26943 (2000).
Amalfitano et al. (Current Gene Therapy 2002, 2: 111-133).
The Department of Health and Human Services has released a memorandum dated Jan. 14, 2003.

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