Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2007-05-22
2007-05-22
Priebe, Scott D. (Department: 1633)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C435S069100, C435S320100, C435S325000, C435S455000, C514S04400A, C536S023200, C536S023500, C536S023100
Reexamination Certificate
active
10349858
ABSTRACT:
The invention relates to methods of optimizing gamma carboxylation of a vitamin K-dependent protein, methods of generating fully gamma carboxylated vitamin K-dependent protein, and compositions comprising chimeric nucleic acids and proteins for use in treatment of vitamin K-dependent disease states.
REFERENCES:
patent: WO 8803926 (1988-06-01), None
Rudolph et al., “Expression, purification, and characterization of recombinant human facotr X,” Prot. Exp. Purif. 10:373-378, 1997.
Dihanich et al., “cDNA sequence of rat prothrombin,” Nucl. Acids Res. 18(14): 4251, 1990.
Camire Rodney M.
High Katherine A.
Larson Peter J.
Stafford Darrel W.
Pillsbury Winthrop Shaw & Pittman LLP
Priebe Scott D.
The Children's Hospital of Philadelphia
The University of North Carolina
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