Enhanced expression of proteins in genetically modified fungi

Details Enhanced expression of proteins in genetically modified fungi Enhanced expression of proteins in genetically modified fungi

2005-09-06

2005-09-06

Wax, Robert A. (Department: 1653)

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

C435S189000, C435S210000, C435S254110, C435S254300, C435S254400, C435S254500, C435S254600, C435S254700, C435S320100, C536S023200

Reexamination Certificate

active

06939704

ABSTRACT:
The present invention relates to increasing the production of a protein of interest from a fugal host. The invention discloses nucleotide sequences comprising, a regulatory region in operative association with xylanase secretion sequence and a gene of interest. The gene of interest encodes a protein selected from a pharmaceutical, nutraceutical, industrial, animal feed, food additive and an enzyme. Preferably, the gene of interest encodes a cellulase, hernicellulase, a lignin degrading enzyme, pectinase, protease, or peroxidase. The present invention also relates to vectors and hosts comprising these nucleic acid sequences, and to methods for the production of a protein of interest.

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