Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1986-05-12
1991-02-12
Teskin, Robin L.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
435 691, 435 91, 4351723, 4352402, 4353201, 530350, 536 27, 935 9, 935 32, 935 39, 935 47, 935 58, 935 62, 935 70, 935 81, C07K 1300, C07H 1512, C12P 2106, C12P 1934, C12N 1500, C12N 500
Patent
active
049923676
ABSTRACT:
Methods and compositions are provided for the high level expression of human interleukin-2 in mammalian cells. This high level expression is produced by the substitution of the normal human 5' noncoding sequences and the AUG initiation codon of the interleukin-2 gene by heterologous corresponding sequences. The expression product is a glycosylated polypeptide which is similar to the natural product and which can be purified to a high degree of purity for use as a therapeutic agent.
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Ellis Joan
Epstein William H.
Gould George M.
Hoffmann-La Roche Inc.
Leon Bernard S.
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