Enhanced delivery of naked DNA to skin by non-invasive in...

Surgery – Means for introducing or removing material from body for... – Treating material introduced into or removed from body...

Reexamination Certificate

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C604S020000

Reexamination Certificate

active

06972013

ABSTRACT:
In vivo methods are provided for using an electric field to delivery therapeutic or immunizing treatment to a subject by applying non-invasive, user-friendly electrodes to the surface of the skin. Thus, therapeutic or immunizing agents can be delivered into cells of skin for local and systemic treatments or for immunization with optimal gene expression and minimal tissue damage. In particular, therapeutic agents include naked or formulated nucleic acid, polypeptides and chemotherapeutic agents.

REFERENCES:
patent: 6520950 (2003-02-01), Hofmann et al.
patent: 6654636 (2003-11-01), Dev et al.
patent: 6678556 (2004-01-01), Nolan et al.
patent: 6697669 (2004-02-01), Dev et al.
patent: 2002/0099323 (2002-07-01), Dev et al.
patent: 2004/0147964 (2004-07-01), Nolan et al.
patent: 2005/0054594 (2005-03-01), Zhang et al.

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