Surgery – Means for introducing or removing material from body for... – Treating material introduced into or removed from body...
Reexamination Certificate
2011-04-12
2011-04-12
Lucchesi, Nicholas D (Department: 3763)
Surgery
Means for introducing or removing material from body for...
Treating material introduced into or removed from body...
C604S020000
Reexamination Certificate
active
07922709
ABSTRACT:
In vivo methods are provided for using an electric field to delivery therapeutic or immunizing treatment to a subject by applying non-invasive, user-friendly electrodes to the surface of the skin. Thus, therapeutic or immunizing agents can be delivered into cells of skin for local and systemic treatments or for immunization with optimal gene expression and minimal tissue damage. In particular, therapeutic agents include naked or formulated nucleic acid, polypeptides and chemotherapeutic agents.
REFERENCES:
patent: 1653819 (1927-12-01), Northcott et al.
patent: 4262672 (1981-04-01), Kief
patent: 4699880 (1987-10-01), Goldstein
patent: 4704692 (1987-11-01), Ladner
patent: 4874500 (1989-10-01), Madou et al.
patent: 4907601 (1990-03-01), Frick
patent: 4991578 (1991-02-01), Cohen
patent: 5019034 (1991-05-01), Weaver et al.
patent: 5053001 (1991-10-01), Reller et al.
patent: 5058605 (1991-10-01), Slovak
patent: 5215088 (1993-06-01), Normann et al.
patent: 5273525 (1993-12-01), Hofmann
patent: 5279544 (1994-01-01), Gross et al.
patent: 5284471 (1994-02-01), Sage, Jr.
patent: 5304120 (1994-04-01), Crandell et al.
patent: 5306236 (1994-04-01), Blumenfield et al.
patent: 5309909 (1994-05-01), Gadsby et al.
patent: 5318514 (1994-06-01), Hoffmann
patent: 5322520 (1994-06-01), Milder
patent: 5328451 (1994-07-01), Davis et al.
patent: 5368704 (1994-11-01), Madou et al.
patent: 5389069 (1995-02-01), Weaver
patent: 5425752 (1995-06-01), Vu'Nguyen
patent: 5439440 (1995-08-01), Hofmann
patent: 5462520 (1995-10-01), Hoffmann
patent: 5464386 (1995-11-01), Hoffmann
patent: 5468223 (1995-11-01), Mir
patent: 5474527 (1995-12-01), Bettinger
patent: 5507724 (1996-04-01), Hofmann et al.
patent: 5507802 (1996-04-01), Imran
patent: 5536267 (1996-07-01), Edwards et al.
patent: 5547467 (1996-08-01), Pliquett et al.
patent: 5554110 (1996-09-01), Edwards et al.
patent: 5589466 (1996-12-01), Felgner et al.
patent: 5667491 (1997-09-01), Pliquett et al.
patent: 5674267 (1997-10-01), Mir et al.
patent: 5688233 (1997-11-01), Hofmann et al.
patent: 5702359 (1997-12-01), Hofmann et al.
patent: 5718702 (1998-02-01), Edwards
patent: 5720921 (1998-02-01), Meserol
patent: 5749847 (1998-05-01), Zewert et al.
patent: 5780052 (1998-07-01), Khaw et al.
patent: 5786454 (1998-07-01), Waksman et al.
patent: 5789213 (1998-08-01), Hui et al.
patent: 5797898 (1998-08-01), Santini et al.
patent: 5807308 (1998-09-01), Edwards
patent: 5807309 (1998-09-01), Lundquist et al.
patent: 5810762 (1998-09-01), Hofmann
patent: 5814599 (1998-09-01), Mitragotri et al.
patent: 5845646 (1998-12-01), Lemelson
patent: 5868740 (1999-02-01), Leveen et al.
patent: 5869326 (1999-02-01), Hofmann
patent: 5873849 (1999-02-01), Bernard
patent: 5874268 (1999-02-01), Meyer
patent: 5879891 (1999-03-01), Thompson
patent: 5908753 (1999-06-01), Kelly et al.
patent: 5911223 (1999-06-01), Weaver et al.
patent: 5944715 (1999-08-01), Goble et al.
patent: 5964726 (1999-10-01), Korenstein et al.
patent: 5968006 (1999-10-01), Hofmann
patent: 5972013 (1999-10-01), Schmidt
patent: 5980517 (1999-11-01), Gough
patent: 5983131 (1999-11-01), Weaver et al.
patent: 5983136 (1999-11-01), Kamen
patent: 5993434 (1999-11-01), Dev et al.
patent: 5994127 (1999-11-01), Selden et al.
patent: 5995869 (1999-11-01), Cormier et al.
patent: 6001617 (1999-12-01), Raptis
patent: 6002961 (1999-12-01), Mitragotri et al.
patent: 6009345 (1999-12-01), Hofmann
patent: 6014584 (2000-01-01), Hoffmann et al.
patent: 6040184 (2000-03-01), Greener et al.
patent: 6041253 (2000-03-01), Köst et al.
patent: 6055453 (2000-04-01), Hofmann et al.
patent: 6110161 (2000-08-01), Mathiesen et al.
patent: 6120493 (2000-09-01), Hofmann
patent: 6192270 (2001-02-01), Hofmann et al.
patent: 6206004 (2001-03-01), Schmidt et al.
patent: 6277116 (2001-08-01), Utely et al.
patent: 6302874 (2001-10-01), Zhang et al.
patent: 6330478 (2001-12-01), Lee et al.
patent: 6520950 (2003-02-01), Hofmann et al.
patent: 6654636 (2003-11-01), Dev et al.
patent: 6678556 (2004-01-01), Nolan et al.
patent: 6697669 (2004-02-01), Dev et al.
patent: 6972013 (2005-12-01), Zhang et al.
patent: 2002/0016562 (2002-02-01), Cormier et al.
patent: 2002/0099323 (2002-07-01), Dev et al.
patent: 2003/0073653 (2003-04-01), Bureau
patent: 2004/0147964 (2004-07-01), Nolan et al.
patent: 2005/0054594 (2005-03-01), Zhang et al.
patent: 863 111 (1953-01-01), None
patent: 40 00 893 (1991-07-01), None
patent: 0 378 132 (1990-07-01), None
patent: 0 378 132 (1991-03-01), None
patent: WO 89/10690 (1989-11-01), None
patent: WO 94/04220 (1994-03-01), None
patent: WO 94/22526 (1994-10-01), None
patent: WO 97/07826 (1997-03-01), None
patent: WO 99/52424 (1999-02-01), None
patent: WO 99/44678 (1999-09-01), None
patent: WO 99/64615 (1999-12-01), None
Gilbert, et al., “Novel Electrode Designs for Electrochemotherapy”, Biochimica et Biophysica Acta, (1997), 9-14, vol. 1334.
Hofmann, et al., “Electrochemotherapy: Transition from Laboratory to the Clinic”, IEEE Engineering in Medicine and Biology, (1996), 124-132.
Okino, et al., “Effects of a High-Voltage Electrical Impulse and an Anticancer Drug on in viv Growing Tumors”, Jpn. J. Cancer Res., (1987), 1319-1321, vol. 78.
Okino, et al., “The Effects of a Single High Voltage Electrical Stimulation with an Anticancer Drug on in vivo Growing Malignant Tumors”, Japanese Journal of Surgery, (1990), 197-204, 20:2.
Okino, et al. “Optimal Electric Conditions in Electrical Impulse Chemotherapy”, Jpn. J. Cancer Res., (1992), 1095-1101, vol. 83.
Titomirov, et al., “In vivo Electroporation and Stable Transformation of Skin Cells of Newborn Mice by Plasmid DNA”, Biophys, Acta, (1991) 131-134, vol. 1088.
Zhang, et al., “Depth Targeted Efficient Gene Deliver and Expression in the Skin by Pulsed Electric Fields; An Approach to Gene Therapy of Skin Aging and Other Diseases”, Biochemical Biophysical. Research Communications, (1996), 633-636, 220:3.
Aihara et al., “Gene transfer into muscle by electroporation in vivo,”Nat. Biotechnol. 16(9):867-870 (1998).
Andree et al., “In vivo Transfer and Expression of a Human Epidermal Growth Factor Gene Accelerates Wound Repair,”Proc. Natl. Acad. Sci. USA91(25):12188-12192 (1994).
Badkar et al., “Enchancement of Transdermal Iontophoretic Delivery of a Liposomal Formulation of Colchicine by Electroporation,”Drug Deliv. 6(2):111-115 (1999).
Budker et al., “Hypothesis: Naked plasmid DNA is taken up by cells in vivo by a receptor-mediated process,”J. Gene Med. 2(2):76-88 (2000).
Carroll et al., “Tissue-and Stratum-Specific Expression of the Human Involucrin Promoter in Transgenic Mice,”Proc. Natl. Acad. Sci. USA90(21):10270-10274 (1993).
Cech, “Ribozymes and Their Medical Implications,”J. Amer. Med. Assn. 260(20):3030-3034 (1988).
Cheng et al., “In vivo Promoter Activity and Transgene Expression in Mammalian Somatic Tissues Evaluated by Using Particle Bombardment,”Proc. Natl. Acad. Sci. USA90(10):4455-4459 (1993).
Choate et al., “Corrective gene transfer into the human skin disorder lamellar ichthyosis,”Nat. Med. 2(11):1263-1267 (1996).
Ciernik et al., “Puncture-Mediated Gene Transfer to the Skin,”Hum. Gene Ther. 7(8):893-899 (1997).
De Luca et al., “The importance of epidermal stem cells in keratinocyte-mediated gene therapy,”Gene Ther. 4(5):381-383 (1997).
Dev et al., “Medical Applications of Electroporation,”IEEE Transactions on Plasma Science28(1):206-223 (2000).
Drabick et al., “Cutaneous Transfection and Immune Responses to Intradermal Nucleic Acid Vaccination Are Significantly Enhanced by in Vivo Electropermeabilization,”Mol. Ther. 3(2):249-255 (2001).
Fakharzadeh et al., “Correction to the coagulation defect in hemophilia A mice through factor VIII expression in skin,”Blood95(9):2799-2805 (2000).
Falo, “Targeting the skin for genetic immunization,”Proc. Assoc. Am. Physicians111(3):211-219 (1999).
Frie
Rabussay Dietmar P.
Zhang Lei
Bouchelle Laura A
Genetronics Inc.
Kim Thomas
Lucchesi Nicholas D
LandOfFree
Enhanced delivery of naked DNA to skin by non-invasive in... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Enhanced delivery of naked DNA to skin by non-invasive in..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Enhanced delivery of naked DNA to skin by non-invasive in... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2666643