Enhanced bioconversion of toxic substances

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing oxygen-containing organic compound

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435232, 435255, 435940, 435942, C12P 726, C12N 988, C12R 1865

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active

051734133

ABSTRACT:
Method and apparatus are provided for the bioconversion of toxic substrates with increased yields of product. The invention makes use of immobilized cells as biocatalyst and complexing agent in either dissolved or solid form. The invention also employs various schemes and apparatus for separating immobilized cells and complexing agent for recycle and re-use in bioconversion reactions. A preferred embodiment of the invention produces improved yields and titers of L-phenylacetyl carbinol by the bioconversion of acetaldehyde using yeast cells.

REFERENCES:
CA 13-76518(8) Mahmoud et al. (Bibiau) V36(1), p. 55-63 (1990).
CA 13-76519(9) Mohmoud et al. (Bibiau) V36(1), pp. 47-54 (1990).
BioTech Abs. 89-14950 Long et al. (Bibiau) V34, 7, pp. 933-941 (1989).
BioTech Abs. 90-10023 WO9004639 (Mar. 5, 1990).
Bar, Appl. Micro Biotech vol. 31, pp. 225-228 (1989).
Arcuri et al., Biotech & Bioeng. vol. 25; pp. 2399-2411 (1983).

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