Enhanced antisense oligonucleotides

Details Enhanced antisense oligonucleotides Enhanced antisense oligonucleotides

2011-04-05

2011-04-05

Zara, Jane (Department: 1635)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

C435S006120, C435S091100, C435S091310, C435S455000, C536S023100, C536S024310, C536S024500

Reexamination Certificate

active

07919472

ABSTRACT:
Described herein are gap-widened antisense oligonucleotides having improved therapeutic index as compared to 5-10-5 MOE gapmer antisense oligonucleotides of the same sequence. Also described are methods of reducing a target RNA in an animal using the gap-widened antisense oligonucleotides of the present invention. Further, are methods for selecting a gap-widened antisense oligonucleotides.

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