Enhanced agglutination method and kit

Details Enhanced agglutination method and kit Enhanced agglutination method and kit

1983-04-20

1987-01-13

Marantz, Sidney

Chemistry: analytical and immunological testing

Involving an insoluble carrier for immobilizing immunochemicals

Carrier is organic

436520, 436534, 436808, 436819, 436829, G01N 33546, G01N 33555

Patent

active

046364790

ABSTRACT:
An enhanced agglutination assay method for determination of a multivalent analyte is disclosed. Analyte is added to agglutinatable particles coated with anti-analyte molecules to produce particle agglutination. The extent of agglutination is enhanced by mixing the particles and analyte with an analyte-binding reagent composed of lipid bodies. The reagent bodies act by promoting multiple analyte bridge connections between individual bridged particles and a reagent body. Also disclosed is a kit containing such particles and reagent.

REFERENCES:
patent: 4216622 (1980-07-01), Soothill et al.
patent: 4429008 (1984-01-01), Martin et al.
Martin et al., "Inversible Coupling of Immunoglobulin Fragments to Profound Vervener", J of Bio Chem, vol. 257, 1/82, pp. 286-288.

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