Drug – bio-affecting and body treating compositions – Lymphokine – Interleukin
Patent
1996-07-22
2000-06-06
Celsa, Bennett
Drug, bio-affecting and body treating compositions
Lymphokine
Interleukin
424 851, 424 854, A61K 4500, A61K 3821
Patent
active
06071509&
ABSTRACT:
An improved method for the prevention of the inactivation of natural killer (NK) cells and the enhanced activation of NK cells in the presence of monocytes using a combination of a natural killer cell activator and a compound effective to inhibit the production or release of intracellular hydrogen peroxide, or a hydrogen peroxide scavenger, is disclosed. The method is useful, for example, in the treatment of solid tumors, metastases and viral infection.
REFERENCES:
patent: 4690915 (1987-09-01), Rosenberg
patent: 5348739 (1994-09-01), Hellstrand et al.
"Remission maintenance therapy with histamine and interleukin-2 in acute myelogenous leukaemia" Brune, et al., British Journal of Haematology, 92:620-626, 1996.
"Hydrogen peroxide as a potent activator of T lymphocyte functions" Los, et al., Eur. Journal of Immunology, 25:159-165, 1995.
"Effect of Reactive Oxygen Intermediates and Antixidants on Proliferation and Function of T Lymphocytes" Droge, et al., Methods in Enzymology, 234:135-151, 1994.
"Antioxidants Inhibit Proliferation and Cell Surface Expression of Receptors for Interleukin-2 and Transferrin in T Lymphocytes Stimulated with Phorbol Myristate Acetate and Ionomycin" Chaudhri, et al., Cellular Immunology, 115:204-213, 1988.
"Hydroxyl radical scavengers inhibit lymphocyte mitogenesis" Novogrodsky, et al., Proc. Natl. Acad. Sci. USA, 79:1171-1174, Feb. 1982.
The Influence of Intraperitoneal Injections of Histamine on Tumor Growth in Fibrosarcoma-Bearing Mice. Burtin, et al., Cancer Letters, 12: 195-201, Jan. 1981.
Successful Tumor Immunotherapy with Cimetidine in Mice, Osband, et al., The Lancet, No. 8221, 1: 636-638, Mar. 21, 1981.
Suppression of Natural Killing in Vitro by Monocytes and Polymorphonuclear Leukocytes. Seaman, et al., The Journal of Clinical Investigation, 69: 876-888. Apr. 1982.
The Differential Effects of Human Leukocytic Pyrogen/Lymphocyte-Activating Factor, T Cell Growth Factor, and Interferon on Human Natural Killer Activity, Dempsey, et al., The Journal of Immunology, May 17, 1982.
Tumor-Enhancing Effects of Cimetidine, Barna, et al., Oncology, 40: 43-45. 1983.
Combination of Cimetidine with other Drugs for Treatment of Cancer, Thornes, et al., New England Journal of Medicine 308: 591-592, Mar. 10, 1983.
The Influence of Histamine on Immune and Inflammatory Responses, Beer, et al., Advances in Immunology, 35: 209-268, 1984.
Hydroxyl radical scavengers inhibit human natural killer cell activity, Suthanthiran, et al., Nature 307: 276-278, Jan. 1984.
Enhancement by serotonin of intra-tumor penetration of spleen cells, Lespinatas, et al., Br. J. Cancer, 50: 545-547, Apr. 5, 1984.
Compared Mechanisms of Tumor Cytolysis by Human Natural Killer Cells and Activated Polymorphonuclear Leukocytes, Abrams, et al., The Journal of Immunology 132: No. 6, 3192-3196, Jun. 1984.
Down-Regulation of Human Natural Killer Activity Against Tumors by the Neutrophil Myeloperoxidase System and Hydrogen Peroxide, El-Hag, et al., The Journal of Immunology 133: No. 6, 3291-3297, Dec. 1984.
Effect of Ascorbic Acid on Human Natural Killer Cells, Huwyler, et al., Immunology Letters, 10: 173-176, 1985.
The Role of Natural Killer Cells in the Control of Tumor Growth and Metastasis, Nabil Hanna. Biochimica et Biophysica Acta. 780: 213-226, 1985.
Induction of Interferon-.gamma. Production by Human Natural Killer Cells Stimulated by Hydrogen Peroxide, Munakata, et al., The Journal of Immunology, 134: No. 4, 2449-2455, Apr. 1985.
Natural Killer Cell-Mediated Lysis Involves an Hydroxyl Radical-Dependent Step, Duwe, et al., The Journal of Immunology, 134: No. 4, 2449-2455, Apr. 1985.
Cytotoxicity by human adherent cells: oxygen-dependent and -independent cytotoxic reactions by different cell populations, Kessel, et al., Immunology, 58: 291-296, 1986.
Histamine augments interleukin-2 production and the activation of cytotoxic T lymphocytes, Chemical Abstracts. 104: No. 146898m, p. 146891.
Histamine Augments Interleukin-2 Production and the Activation of Cytotoxic T Lymphocytes, Droge, et al., Immunopharmacology, 11: 1-6, 1986.
Histamine Inhibits Interferon-.gamma. Production via Suppression of Interleukin 2 Synthesis, Dohlsten, et al., Cellular Immunology, 101: 493-501, 1986.
Histamine-Induced Suppressor Factor Inhibition of NK Cells: Reversal with Interferon and Interleukin 2, Nair, et al., The Journal of Immunology, 136: No. 7, 2456-2462, Apr. 1, 1986.
Hydeoperoxide Metabolism in Cyanobacteria, Tel-Or. et al., Archives of Biochemistry and Biophysics, 246: No. 1, 396-402, Apr. 1986.
Histamine H.sub.2 -Receptor-Mediated Regulation of Human Natural Killer Cell Activity, Hellstrand, et al., The Journal of Immunology, 137: No. 2, Jul. 15, 1986.
Biogenic Amines in the Regulation of Human Natural Killer Cell Cytotoxicity, Hellstrand, 1987.
Differential Effects of Histamine Receptor Antagonists on Human Natural Killer Cell Activity, Hellstrand, et al., Int. Archs Allergy appl. Immunology, 84: 247-255, 1987.
Selective, Histamine-Mediated Immunosuppression in Laryngeal Cancer, Richtsmeier, et al., Ann Otol Rhinol Laryngol, 96: No. 5, 569-572, 1987.
Clinical Improvement in Advanced Cancer Disease After Treatment Combining Histamine and H2-Antihistaminics (Ranitidine or Cimetidine), Burtin, et al., Accepted Jun. 1987.
Role of Serotonin in the Regulation of Human Natural Killer Cell Cytotoxicity, Hellstrand, et al., The Journal of Immunology, 139: No. 3, Aug. 1, 1987.
The IL-2 Receptor .beta. Chain (p70): Role in Mediating Signals for LAK, NK, and Proliferative Activities, Siegel, et al., Science, vol. 238, Oct. 2, 1987.
Chondrocyte Antioxidant Defenses: The Roles of Catalase and Glutathione Peroxidase in Protection Against H.sub.2 O.sub.2 Dependent Inhibition of Proteoglycan Biosynthesis, Baker, et al., The Journal of Rheumatology, 15: No. 4, 670-677, 1988.
Role of Flavonoids in the Oxygen-Free Radical Modulation of the Immune Response, Pignol, et al., Plant Flavonoids in Biology & Medicine II: Biochemical, Cellular . . . 173-182, 1988.
Flavone-8-Acetic Acid Augments Systemic Natural Killer Cell Activity and Synergizes with IL-2 for Treatment of Murine Renal Cancer, Wiltrout, et al., The Journal of Immunology, 140: No. 9, 3261-3265, May 1, 1988.
Interleukin-2: Inception, Impact, and Implications, Kendall A. Smith, Science, 240: 1169-1176, May 27, 1988.
Enhancement of Natural Killer Activity in Human Peripheral Blood by Flavone Acetic Acid, Urba, et al., The Journal of the National Cancer Institute, 80: No. 7, 521-525, Jun. 1, 1988.
The Development of New Immunotherapies for the Treatment of Cancer Using Interleukin-2, Rosenberg, Annals of Surgery, 208: No. 2, 121-135, Aug. 1988.
Interleukin 2 as a Pharmacologic Reagent, Lotze, et al., Chapter 12 from the National Institutes of Health, Oct. 28, 1988.
Augmentation of Natural Killer Activity, Induction of IFN and Development Tumor Immunity During the Successful Treatment of Established Murine Renal Cancer Using Flavone Acetic Acid and IL-2, Hornung, et al., The Journal of Immunology, 141: No. 10, 3671-3679, Nov. 15, 1988.
Enhancement of Human Natural Killer Cell Function by the Combined Effects of Tumor Necrosis Factor .alpha. or Interleukin-1 and Interferon-.alpha. or Interleukin-2, .O slashed.stensen, et al., Journal of Biological Response Modifiers, 8: 53-61, 1989.
Suppression of human natural killer cell cytotoxicity by interleukin-2, Hellstrand, et al., Clin. Exp. Immunol. 77: 410-416, 1989.
Comparative Effect of Recombinant Il-1, -2, -3, -4, and -6, IFN-.gamma., Granulocyte-Macrophage-Colony-Stimulating Factor, Tumor Necrosis Factor-.alpha., and Histamine-Releasing Factors on the Secretion of Histamine From Basophils, Alam, et al., The Journal of Immunology, 142: No. 10, 3431-3435, May 18, 1989.
Activation of Natural Killer Cells via the p75 Interleukin 2 Receptor, Phillips, et al., J. Exp. Med., 170: 291-296, Jul. 1989.
Inhibition of Lymphokine-Activated Killer-and Natural Killer-Mediated Cytotoxicities by Neutrophils, Shau, et al., The Journal of Immunology, 143: No. 3, 1066-1072, Aug. 1989.
Regulation of Human Basophil Mediator Release by Cyto
Hellstrand Jan Urban Kristoffer
Hermodsson Svante Hermod
Celsa Bennett
Garcia Maurie
Maxim Pharmaceuticals, Inc.
LandOfFree
Enhanced activation of natural killer cells using an NK cell act does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Enhanced activation of natural killer cells using an NK cell act, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Enhanced activation of natural killer cells using an NK cell act will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2211171