Enhanced absorption of psychoactive 2-aryl-pyrazolo quinolines a

Details Enhanced absorption of psychoactive 2-aryl-pyrazolo quinolines a Enhanced absorption of psychoactive 2-aryl-pyrazolo quinolines a

1987-01-20

1988-07-19

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

Lymphokine

A61K 1700, A61K 3147

Patent

active

047584270

ABSTRACT:
The absorption of orally administered substantially aqueous insoluble psychoactive 2-aryl-pyrazolo [4,3-C] quinolin-3-ones of the formula ##STR1## where R" is hydrogen, lower alkyl, lower alkoxy, hydroxy, halo or trifluoromethyl, and R' is hydrogen, lower alkyl, lower alkoxy, hydroxy, halo, trifluoromethyl, nitro, amino, mono- or di-lower alkylamino, mono- or di-lower alkylcarbamoylamino, mono- or di-lower alkylcarbamoyloxy or cyano, or a pharmaceutically acceptable salt thereof, is enhanced by administering the same in the form of a storage stable solid molecular dispersion of polyvinylpyrrolidone.

REFERENCES:
patent: 3895113 (1975-07-01), Omodei-Sale et al.
patent: 4038476 (1977-07-01), Atasoy et al.
patent: 4259331 (1981-03-01), Armstrong
patent: 4312870 (1982-01-01), Yokoyama
patent: 4374826 (1983-02-01), Armstrong
patent: 4524146 (1985-06-01), Yokoyama

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