Multicellular living organisms and unmodified parts thereof and – Nonhuman animal
Patent
1996-11-06
1999-02-02
Stanton, Brian R.
Multicellular living organisms and unmodified parts thereof and
Nonhuman animal
800DIG1, 800DIG2, 800DIG3, 800DIG4, 424 91, 424 92, 4351723, C12N 500
Patent
active
058667571
ABSTRACT:
Non-human chimeric mammals are created from a mammal having hematopoietic cells replaced with hematopoietic cells from a hematopoietic deficient mammal donor, and optionally in which xenogeneic cells and/or tissue are engrafted. The xenogeneic, preferably human, cells or tissue may be hematopoietic cells, in which case the chimeric mammal can produce xenogeneic B and/or T cells, and can be used as a source of mammalian, preferably human, monoclonal antibodies and/or T cells. Alternatively, the xenogeneic cells or tissue may be non-hematopoietic, such as normal or pathological cells or tissue, which can form a stable transplant in the chimeric mammal and thus can be used as an animal model of various pathologies or to test therapeutic or diagnostic agents or modalities. As a further alternative, the xenogenic cells or tissue may be a combination of hematopoietic and non-hematopoietic cells or tissue (which may be allogenic to one another) and, the resultant chimeric mammal can thus be used as an animal model of tissue rejection or to test therapeutic or diagnostic agents or modalities for use with respect to tissue rejection.
REFERENCES:
patent: 4683200 (1987-07-01), Hirohashi
patent: 5147784 (1992-09-01), Peault
Namikawa, R. et al, "Long-term Human Hematopoiesis in the SCID-hu Mouse ", J. Exp. Med. 172:1055-1063 (1990).
Sykes, M. et al, "Mixed Allogeneic Chimerism as an Approach to Transplantation Tolerance", Immunology Today 9(1): 23-27 (1988).
Lubin, I. et al., "Engraftment and Development of Human T and B Cells in Mice After Bone Marrow Transplantation", Science, vol. 252, Apr. 19, 427-431.
McCume, J.M. et al., "Pseudotypes in HIV-Infected Mice", Science250:1152-1154 (1990).
Miyama-Inaba, M. et al., "Isolation of Murine Pluripotent Hemopoietic Stem Cells in the Go Phase", Biochemical and Biophysical Research Communications, 147(2):687-695 (1987).
Mosier, D.E. et al, "Tranfer of a Functional Human Immune System to Mice With Severe Combined Immunodeficiency", Nature225:256-259 (1988).
Namikawa, R. et al., "Infection of the SCID-hu Mouse by HIV-1", Science242:1684-1686 (1988).
Van Bekkum, D.W., et al, "Immune Reconstitution of Radiation Chimeras", Bone Marrow Transplantation: Biological Mechanisms and Clinical Practice, Dekker, New York, pp. 311-350.
Reisner, Y. et al, "Transplantation for Severe Combined Immunodeficiency with HLA-A,B,D,DR Incompatible Parental Marrow Cells Fractioned by Soybean Agglutinin and Sheep Red Blood Cells",Blood61:341 (1983).
Keever, C.A. et al, "Immune Reconstitution following Bone Marrow Transplantation: Comparison of Recipients of T-Cells Depleted Marrow With Recipients of Conventional Marrow Grafts", Blood73:1340 (1989).
Schuler, W. et al, "Rearrangement of Antigen Receptor Genes is Defective in Mice with Severe Combined Immune Deficiency", Cell46:963-972 (1986).
Reisner, Y. et al., "Transplantation for Acute Leukaemia with HLA-A and B Nonidentical Parental Marrow Cells Fractionated with Soybean Agglutinin and Sheep Red Blood Cells", Lancetii:327 (1987).
Furukawa, Toshiharu et al., "Production of Human Immunoglobulin in G Reactive Against Human Cancer in Tumorbearing Mice with Severe Combined Immunodeficiency Reconstituted with Human Splenic Tissues.", Jpn. J. Cancer Res., 83, 894-898, Aug. 1992, pp. 894-898.
Kawamura, Takenori et al., "Chronic Human skin graft rejection in severe combined immunodeficient mice engrafted with human pbl from an hla-presenitized donor.", Transplantation, vol. 53, No. 3, Mar. 1992, pp. 659-665.
Murphy, William J. et al., "Engraftment and Activity of Anti-CD3-Activated Human Peripheral Blood Lympocytes Transferred into Mice with Severe Combined Immune Deficiency.", The Journal of Immunologyvol. 150, No. 8, Apr. 15,1993, pp. 3634-3642.
Galun, E. et al., "Hepatitis C viremia in Chimeric Mice", Hepatology, vol. 20, No. 4/2, p. 232A, Oct. 1994.
Lubin, I. et al., "Engraftment of Human Peripheral Blood Lymphocytes in Normal Strains of Mice", Blood, vol. 83, No. 8, pp. 2368-2381, 15, Apr. 1994.
Mosier, D.E., "Adoptive Transfer of Human Lymphoid Cells to Severely Immundeficient Mice: Models for Normal Human Immune Function, Autoimmunity, Lymphomagenseis, and AIDS", Advances in Immunology, vol 50, pp. 303-325, 1991.
Shimizu, Y.K. et al., "Correlation Between the Infectivity of Hepatitis C Virus in Vivo and its Infectivity in Vitro", PNAS, vol. 90, pp. 6037-6041, Jul. 1993.
Barry et al., "Successful Engraftment of Human Postnatal Thymus in Severe Combined Immune Deficient (SCID) Mice: Differential Engraftment of Thymic Components with Irradiation Versis Anti-asialo GM-1 Immuno-Suppressive Regimens", J. Exp. Med., 173:167-180 (1991).
Bosma et al., "A Severe Combined Immunodeficiency Mutation in the Mouse", Nature301:527-531 (1983).
Giovanella et al, "Heterotransplantation of Human Cancers into Nude Mice", Cancer, 42:2269-2281 (1978).
Kamel-Reid et al., "Engraftment of Immune-Deficient Mice with Human Hematopoietic Stem Cells", Science, 242:1706-1708 (1988).
Kamel-Reid et al, "A Model Human Acute Lymphoblastic Leukemia in Immune-Deficient SCID Mice", Science, 246:1597-1600 (1989).
McCune et al., "The SCID-hu Mouse: Murine Model for the Analysis of Human Hematolymphoid Differentiation and Function", Science, 241:1632-1639 (1988).
Murphy, W. et al., "An Absence of T Cells in Murine Bone Marrow Allografts Leads to an Increased Susceptibility to Rejection by Natural Killer Cells and T Cells", Journal of Immunology, 144:3305-3311 (1990).
Nakamura, T. et al., "Successful Liver Allografts in Mice by Combination with Allogeneic Bone Marrow Transplantation"Proc. Natl. Acad. Sci. USA, 83:4529-4532 (1986).
Clark Deborah J.R.
Stanton Brian R.
Yeda Research and Development Co. Ltd.
LandOfFree
Engraftment and development of xenogeneic cells in normal mammal does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Engraftment and development of xenogeneic cells in normal mammal, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Engraftment and development of xenogeneic cells in normal mammal will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1118945