Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing – Testing efficacy or toxicity of a compound or composition
Patent
1994-11-23
1998-01-20
Stanton, Brian R.
Drug, bio-affecting and body treating compositions
In vivo diagnosis or in vivo testing
Testing efficacy or toxicity of a compound or composition
424 91, 424 931, 424 933, 424 937, 424 9371, 424520, 435 4, 435 5, 800 2, A61K 4900, G01N 3100, A01N 6300, A01N 6500
Patent
active
057098433
ABSTRACT:
Non-human chimeric mammals are created from a mammal having hematopoietic cells replaced with hematopoietic cells from a hematopoietic deficient mammal donor, and optionally in which xenogeneic cells and/or tissue are engrafted. The xenogeneic, preferably human, cells or tissue may be hematopoietic cells, in which case the chimeric mammal can produce xenogeneic B and/or T cells, and can be used as a source of mammalian, preferably human, monoclonal antibodies and/or T cells. Alternatively, the xenogeneic cells or tissue may be non-hematopoietic, such as normal or pathological cells or tissue, which can form a stable transplant in the chimeric mammal and thus can be used as an animal model of various pathologies or to test therapeutic or diagnostic agents or modalities.
REFERENCES:
patent: 4683200 (1987-07-01), Hirohashi et al.
patent: 5147784 (1992-09-01), Peault
Lubin, I. et al., "Engraftment and Development of Human T and B Cells in Mice After Bone Marrow Transplantation", Reports, Apr. 19, 1992, pp. 427-431.
Murphy, W. et al., "An Absence of T Cells in Murine Bone Marrow Allografts Leads to an Increased Susceptibility to Rejection by Natural Killer Cells and T Cells", Journal of Immunology 144:3305-11 (1990).
McCune, J.M. et al., "The SCID-hu Mouse: Murine Model for the Analysis of Human Hematolymphoid Differentiation and Function", Science 241:1632 (1988).
Sykes, M. et al., "Mixed Allogeneic Chimerism as an Approach to Transplantation Tolerance", Immunology Today 9(1):23-27 (1988).
Bosma, G.C., et al., "A Severe Combined Immunodeficiency Mutation in the Mouse", Nature 301:527 (1983).
Nakamura, T. et al., "Successful Liver Allografts in Mice by Combination with Allogeneic Bone Marrow Transplantation", Proc. Natl. Acad. Sci. USA 83:4529 (1986).
Kamel-Reid, S. et al., "A Model Human Acute Lymphoblastic Leukemia in Immune-Deficient SCID Mice", Science 246:1597 (1989).
Kamel-Reid, S. et al., "Engraftment of Immune-Deficient Mice with Human Hematopoietic Stem Cells", Science 242:1706 (1989).
McCune, J.M. et al., "Pseudotypes in HIV-Infected Mice", Science 250:1152-1154 (1990).
Miyama-Inaba, M. et al., "Isolation of murine pluripotent hemopoietic stem cells in the Go phase", Biochemical and Biophysical Research Communications, 147(2):687-695 (1987).
Mosier, D.E. et al., "Transfer of a functional human immune system to mice with severe combined immunodeficiency", Nature 225:256-259 (1988).
Namikawa, R. et al., "Infection of the SCID-hu Mouse by HIV-1", Science 242:1684-1686 (1988).
Namikawa, R. et al., "Long-Term Human Hematopoiesis in the SCID-hu Mouse", J. Exp. Med. 172:1055-1063 (1990).
Reisner, Y. et al., "Transplantation for Severe Combined Immunodeficiency With HLA-A,B,D,DR Incompatible Parental Marrow Cells Fractioned by Soybean Agglutinin and Sheep Red Blood Cells", Blood 61:341 (1983).
Keever, C.A. et al. "Immune Reconstitution Following Bone Marrow Transplantation: Comparison of Recipients of T-Cell Depleted Marrow With Recipients of Conventional Marrow Grafts", Blood 73:1340 (1989).
Schuler, W. et al., "Rearrangement of Antigen Receptor Genes Is Defective in Mice with Severe Combined Immune Deficiency", Cell 46:963-972 (1986).
Reisner, Y. et al., "Transplantation for Acute Leukaemia with HLA-A and B Nonidentical Parental Marrow Cells Fractioned with Soybean Agglutinsin and Sheep Red Blood Cells", Lancet ii:327 (1987).
Barry et al., "Successful Engraftment of Human Postnatal Thymus in Severe Combined Immune Deficient (SCID) Mice: Differential Engraftment of Thymic Components With Irradiation Versis Anti-asialo GM-1 Immuno-Suppressive Regimens", J. Exp. Med. 173:167-180 (1991).
Kamel-Reid, et al., "A Model of Human Acute Lymphoblastic Leukemia in Immune-Deficient SCID Mice", Reports, 22:1597-1600 (1989).
Van Bekkum, D.W., et al., Bone Marrow Transplantation: Biological Mechanisms and Clinical Practice, Dekker, New York, pp. 311-350.
Giovanella et al, "Heterotransplantation of Human Cancers into Nude Mice", Cancer 42:2269-2281 (1978).
Stanton Brian R.
Yeda Research and Development Co. Ltd.
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