Multicellular living organisms and unmodified parts thereof and – Nonhuman animal
Patent
1993-05-17
1997-07-29
Stanton, Brian R.
Multicellular living organisms and unmodified parts thereof and
Nonhuman animal
424 91, 424 92, 424 931, 424577, 4351723, A61K 4900, A61K 3512, C12N 1501
Patent
active
056523734
ABSTRACT:
Non-human chimeric mammals are created from a mammal having hematopoietic cells replaced with hematopoietic cells from a hematopoietic deficient mammal donor, and optionally in which xenogeneic cells and/or tissue are engrafted. The xenogeneic, preferably human, cells or tissue may be hematopoietic cells, in which case the chimeric mammal can produce xenogeneic B and/or T cells, and can be used as a source of mammalian, preferably human, monoclonal antibodies and/or T cells. Alternatively, the xenogeneic cells or tissue may be non-hematopoietic, such as normal or pathological cells or tissue, which can form a stable transplant in the chimeric mammal and thus can be used as an animal model of various pathologies or to test therapeutic or diagnostic agents or modalities.
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Stanton Brian R.
Yeda Research and Development Co. Ltd.
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